Metabolomics of Pregnancy Complications:Emerging Application of Maternal Hair

Delplancke, Thibaut D.J., Wu, Yue, Han, Ting Li, Joncer, Lingga R., Qi, Hongbo, Tong, Chao and Baker, Philip N. (2018) Metabolomics of Pregnancy Complications:Emerging Application of Maternal Hair. BioMed Research International, 2018. pp. 1-19. ISSN 2314-6133

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Abstract

In recent years, the study of metabolomics has begun to receive increasing international attention, especially as it pertains to medical research. This is due in part to the potential for discovery of new biomarkers in the metabolome and to a new understanding of the "exposome", which refers to the endogenous and exogenous compounds that reflect external exposures. Consequently, metabolomics research into pregnancy-related issues has increased. Biomarkers discovered through metabolomics may shed some light on the etiology of certain pregnancy-related complications and their adverse effects on future maternal health and infant development and improve current clinical management. The discoveries and methods used in these studies will be compiled and summarized within the following paper. A further focus of this paper is the use of hair as a biological sample, which is gaining increasing attention across diverse fields due to its noninvasive sampling method and the metabolome stability. Its significance in exposome studies will be considered in this review, as well as the potential to associate exposures with adverse pregnancy outcomes. Currently, hair has been used in only two metabolomics studies relating to fetal growth restriction (FGR) and gestational diabetes mellitus (GDM).

Item Type:	Article
Uncontrolled Keywords:	biochemistry, genetics and molecular biology(all),immunology and microbiology(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	16 Feb 2026 17:30
Last Modified:	16 Feb 2026 17:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101965
DOI:	10.1155/2018/2815439

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