Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy

de Seymour, Jamie V., Tu, Stephanie, He, Xiaoling, Zhang, Hua, Han, Ting Li, Baker, Philip N. ORCID: https://orcid.org/0000-0002-4592-6427 and Sulek, Karolina (2018) Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy. Metabolomics, 14 (6). pp. 1-5. ISSN 1573-3882

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Abstract

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective: Investigate the maternal hair metabolome for predictive biomarkers of ICP.  Methods: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry.  Results: Of 105 metabolites detected in hair, none were significantly associated with ICP.  Conclusion: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.

Item Type:	Article
Additional Information:	The authors would like to acknowledge Associate Professor Silas Villas Boas for his contributions to the hair metabo-lomics method development
Uncontrolled Keywords:	gas chromatography–mass spectrometry,hair,intrahepatic cholestasis of pregnancy,metabolomics,endocrinology, diabetes and metabolism,biochemistry,clinical biochemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2712
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	16 Feb 2026 16:30
Last Modified:	18 Jun 2026 20:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101957
DOI:	10.1007/s11306-018-1371-7

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