Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy

de Seymour, Jamie V., Tu, Stephanie, He, Xiaoling, Zhang, Hua, Han, Ting Li, Baker, Philip N. and Sulek, Karolina (2018) Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy. Metabolomics, 14 (6). pp. 1-5. ISSN 1573-3882

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Abstract

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective: Investigate the maternal hair metabolome for predictive biomarkers of ICP.  Methods: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry.  Results: Of 105 metabolites detected in hair, none were significantly associated with ICP.  Conclusion: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.

Item Type:	Article
Additional Information:	The authors would like to acknowledge Associate Professor Silas Villas Boas for his contributions to the hair metabo-lomics method development
Uncontrolled Keywords:	gas chromatography–mass spectrometry,hair,intrahepatic cholestasis of pregnancy,metabolomics,endocrinology, diabetes and metabolism,biochemistry,clinical biochemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2712
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	16 Feb 2026 16:30
Last Modified:	16 Feb 2026 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101957
DOI:	10.1007/s11306-018-1371-7

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