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ToolsDelplancke, Thibaut D.J., De Seymour, Jamie V., Tong, Chao, Sulek, Karolina, Xia, Yinyin, Zhang, Hua, Han, Ting Li and Baker, Philip N. (2018) Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy. Scientific Reports, 8 (1). pp. 1-12. ISSN 2045-2322
Full text not available from this repository.Abstract
The hair metabolome has been recognized as a valuable source of information in pregnancy research, as it provides stable metabolite information that could assist with studying biomarkers or metabolic mechanisms of pregnancy and its complications. We tested the hypothesis that hair segments could be used to reflect a metabolite profile containing information from both endogenous and exogenous compounds accumulated during the nine months of pregnancy. Segments of hair samples corresponding to the trimesters were collected from 175 pregnant women in New Zealand. The hair samples were analysed using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. In healthy pregnancies, 56 hair metabolites were significantly different between the first and second trimesters, while 62 metabolites were different between the first and third trimesters (p < 0.05). Additionally, three metabolites in the second trimester hair samples were significantly different between healthy controls and women who delivered small-for-gestational-Age infants (p < 0.05), and ten metabolites in third trimester hair were significantly different between healthy controls and women with gestational diabetes mellitus (p < 0.01). The findings from this pilot study provide improved insight into the changes of the hair metabolome during pregnancy, as well as highlight the potential of the maternal hair metabolome to differentiate pregnancy complications from healthy pregnancies.
| Item Type: | Article |
|---|---|
| Additional Information: | The authors wish to acknowledge Nicola Armstrong and Melinda Thomas for their role in the collection and biobanking of the samples in this cohort, and Dr. Silas Villas-Bôas for his role as an advisor on the metabolomic analysis of hair samples. |
| Uncontrolled Keywords: | general,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1000 |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 Jan 2026 16:30 |
| Last Modified: | 26 Jan 2026 01:07 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/101681 |
| DOI: | 10.1038/s41598-017-18317-7 |
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