Tools
Tools
Liao, Shutan, Vickers, Mark H., Stanley, Joanna L., Baker, Philip N. 
ORCID: https://orcid.org/0000-0002-4592-6427 and Perry, Jo K.
(2018)
Human Placental Growth Hormone Variant in Pathological Pregnancies.
Endocrinology, 159 (5).
pp. 2186-2198.
ISSN 0013-7227
Abstract
Growth hormone (GH), an endocrine hormone, primarily secreted from the anterior pituitary, stimulates growth, cell reproduction, and regeneration and is a major regulator of postnatal growth. Humans have two GH genes that encode two versions of GH proteins: a pituitary version (GH-N/GH1) and a placental GH-variant (GH-V/GH2), which are expressed in the syncytiotrophoblast and extravillous trophoblast cells of the placenta. During pregnancy, GH-V replaces GH-N in the maternal circulation at mid-late gestation as the major circulating form of GH. This remarkable change in spatial and temporal GH secretion patterns is proposed to play a role in mediating maternal adaptations to pregnancy. GH-V is associated with fetal growth, and its circulating concentrations have been investigated across a range of pregnancy complications. However, progress in this area has been hindered by a lack of readily accessible and reliable assays for measurement of GH-V. This review will discuss the potential roles of GH-V in normal and pathological pregnancies and will touch on the assays used to quantify this hormone.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | endocrinology ,/dk/atira/pure/subjectarea/asjc/1300/1310 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 Jan 2026 15:30 |
| Last Modified: | 18 Jun 2026 20:51 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/101677 |
| DOI: | 10.1210/en.2018-00037 |
Actions (login required)
 |
View Item |