Human Placental Growth Hormone Variant in Pathological Pregnancies

Liao, Shutan, Vickers, Mark H., Stanley, Joanna L., Baker, Philip N. and Perry, Jo K. (2018) Human Placental Growth Hormone Variant in Pathological Pregnancies. Endocrinology, 159 (5). pp. 2186-2198. ISSN 0013-7227

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Abstract

Growth hormone (GH), an endocrine hormone, primarily secreted from the anterior pituitary, stimulates growth, cell reproduction, and regeneration and is a major regulator of postnatal growth. Humans have two GH genes that encode two versions of GH proteins: a pituitary version (GH-N/GH1) and a placental GH-variant (GH-V/GH2), which are expressed in the syncytiotrophoblast and extravillous trophoblast cells of the placenta. During pregnancy, GH-V replaces GH-N in the maternal circulation at mid-late gestation as the major circulating form of GH. This remarkable change in spatial and temporal GH secretion patterns is proposed to play a role in mediating maternal adaptations to pregnancy. GH-V is associated with fetal growth, and its circulating concentrations have been investigated across a range of pregnancy complications. However, progress in this area has been hindered by a lack of readily accessible and reliable assays for measurement of GH-V. This review will discuss the potential roles of GH-V in normal and pathological pregnancies and will touch on the assays used to quantify this hormone.

Item Type:	Article
Uncontrolled Keywords:	endocrinology ,/dk/atira/pure/subjectarea/asjc/1300/1310
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	22 Jan 2026 15:30
Last Modified:	22 Jan 2026 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101677
DOI:	10.1210/en.2018-00037

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