Postnatal Subacute Benzo(a)Pyrene Exposure Caused Neurobehavioral Impairment and Metabolomic Changes of Cerebellum in the Early Adulthood Period of Sprague-Dawley Rats

Li, Chunlin, Wang, Jing, Su, Qiuping, Yang, Kai, Chen, Chengzhi, Jiang, Xue Jun, Han, Tingli, Cheng, Shuqun, Mo, Tingting, Zhang, Ruiyuan, Peng, Bin, Guo, Yuming, Baker, Philip N., Tu, Baijie and Xia, Yinyin (2018) Postnatal Subacute Benzo(a)Pyrene Exposure Caused Neurobehavioral Impairment and Metabolomic Changes of Cerebellum in the Early Adulthood Period of Sprague-Dawley Rats. Neurotoxicity Research, 33 (4). pp. 812-823. ISSN 1029-8428

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Abstract

Benzo(a)pyrene (BaP) is a widespread environmental contaminant that has been associated with neurotoxicity in mammals. It has strong toxic effects on the developing central nervous system. Cerebellum is associated with locomotor activity and anxiety behavior, but there is very little research about the toxic effects of BaP in cerebellum. The present study aims to investigate the global influence of BaP subacute exposure on the metabolome of rat cerebellum. Male neonatal rats (postnatal day 5) were divided into two groups: control group and BaP-treated group (2 mg/kg/day for 7 weeks). Open field test and transmission electron microscopy were performed to analyze neurobehavior and ultramicrostructure alteration. Gas chromatography-mass spectrometry (GC-MS) was used to analyze metabolites of the cerebellum in both groups. The results revealed that postnatal exposure to BaP promoted pathological changes in the cerebellum and increased locomotor and anxiety activities in early adulthood. Twenty differential significant metabolites were identified by multivariate statistical analysis. Further metabolic pathway impact analysis and network analysis suggested that the primary metabolic pathways affected included pathway involved in energy metabolism, methionine and cysteine metabolism, and glutathione metabolism. These findings suggest that BaP-induced cerebellum injury may be correlated with metabolic changes and provide an area to target to reduce the negative effects of BaP.

Item Type:	Article
Uncontrolled Keywords:	benzo(a)pyrene,cerebellum,gas chromatography-mass spectrometry,metabolomics,neonatal rat,neuroscience(all),toxicology ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	22 Jan 2026 15:30
Last Modified:	23 Jan 2026 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101676
DOI:	10.1007/s12640-017-9832-8

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