Pineal gland senescence: an emerging ageing-related pathology?

Short, Emma; Ajjan, Ramzi; Barber, Thomas M.; Bhandari, Sunil; Chazot, Paul; Garrison, Jennifer L.; Goyal, Anushka; Huckstepp, Robert; Jamal, Noordin; Kanamarlapudi, Venkateswarlu; Lazar, Alpar; Lee, Thomas; Tavares, Adriana A. S.; Tree, Jeremy J.; Wellington, Jack; Calimport, Stuart R. G.; Bentley, Barry

doi:10.1007/s42000-025-00720-9

Pineal gland senescence: an emerging ageing-related pathology?

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Short, Emma, Ajjan, Ramzi, Barber, Thomas M., Bhandari, Sunil, Chazot, Paul, Garrison, Jennifer L., Goyal, Anushka, Huckstepp, Robert, Jamal, Noordin, Kanamarlapudi, Venkateswarlu, Lazar, Alpar, Lee, Thomas, Tavares, Adriana A. S., Tree, Jeremy J., Wellington, Jack, Calimport, Stuart R. G. and Bentley, Barry (2025) Pineal gland senescence: an emerging ageing-related pathology? International Journal of Endocrinology and Metabolism. ISSN 1726-913X

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Abstract

An ageing-related pathology has recently been described as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline and that is evidenced by studies in humans. The pineal gland is a photo-neuroendocrine organ whose primary function is to produce and secrete melatonin in response to light-dark cycle environmental cues. The gland may undergo ageing-related structural and morphological changes, including calcification, gliosis, cyst formation, and reduced density of β-adrenergic receptors, which are hypothesised to reduce melatonin secretion. Pineal gland senescence describes the ageing-related decline in neuroendocrine function, with reduced secretion of melatonin, which may contribute to ageing-related sleep disorders and disruption of other circadian-driven physiological functions and may have secondary effects such as contributing to cognitive and mood disorders related to sleep disturbance.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health) Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Related URLs:	https://link.springer.com/article/10.100...
Depositing User:	LivePure Connector
Date Deposited:	23 Dec 2025 15:30
Last Modified:	23 Dec 2025 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101499
DOI:	10.1007/s42000-025-00720-9

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