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ToolsMicek, Agnieszka, Godos, Justyna, Giampieri, Francesca, Battino, Maurizio, Quiles, José L., Del Rio, Daniele, Mena, Pedro, Caruso, Giuseppe, Frias-Toral, Evelyn, Azpíroz, Irma Domínguez, Xiao, Jianbo, Veronese, Nicola, Siervo, Mario, Vauzour, David, Ungvari, Zoltan, Galvano, Fabio and Grosso, Giuseppe and on behalf of the International Network for Evidence on Phytochemicals, Biotics for Human Health (2025) The effect of anthocyanins and anthocyanin-rich foods on cognitive function: A meta-analysis of randomized controlled trials. GeroScience. ISSN 1574-4647
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Abstract
The rising prevalence of cognitive disorders highlights the urgent need for effective prevention strategies and therapeutic interventions. While adherence to a balanced diet has been associated with a reduced risk of cognitive decline, emerging evidence underscores the potential role of plant-derived bioactive compounds, such as (poly)phenols, with anthocyanins receiving increasing attention. This meta-analysis aimed to evaluate the effect of anthocyanin- rich interventions on cognitive performance. A systematic search of randomized controlled trials (RCTs) assessing the effects of anthocyanin supplementation and cognitive outcomes identified 59 eligible studies. Overall, anthocyanin intervention significantly improved global cognition (standardized mean difference (SMD) = 0.46, 95% CI = 0.30 to 0.63, I2 = 0.0%) compared with controls. Domain specific analyses further revealed significant benefits for visuospatial processing/reasoning and attention (SMD = 0.37, 95% CI = 0.18 to 0.55, I2 = 76.3%), processing and psychomotor speed (SMD = 0.19, 95% CI = 0.05 to 0.34, I2 = 64.0%), verbal speed and fluency (SMD = 0.21, 95% CI = 0.03 to 0.39, I2 = 30.5%), episodic memory (SMD = 0.30, 95% CI = 0.10 to 0.50, I2 = 75.9%), and working memory (SMD = 0.24, 95% CI = 0.12 to 0.36, I2 = 46.5%). Collectively, these findings suggest that anthocyanin supplementation may improve multiple cognitive domains. Although these results are promising, further well-designed RCTs are needed to validate these outcomes and consolidate the current evidence base.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability: Not applicable. Funding: The study was carried out as a part of the project supported by the National Science Centre in Poland: “MINIATURA 7” (No. 2023/07/X/NZ7/01127; granted to A.M.). This work was also supported by the Italian Ministry of Health (Ricerca Corrente). |
| Uncontrolled Keywords: | anthocyanins,flavonoids,polyphenols,cognition,memory,brain,neuroscience(all),sdg 3 - good health and well-being,3* ,/dk/atira/pure/subjectarea/asjc/2800 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 16 Dec 2025 15:30 |
| Last Modified: | 16 Dec 2025 15:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/101427 |
| DOI: | 10.1007/s11357-025-02008-7 |
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