In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy

Bell, J. D., Cox, I. J., Williams, S. C. R., Belton, P. S., McConnell, I. and Hope, J. ORCID: https://orcid.org/0000-0003-2015-2389 (1991) In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy. Journal of General Virology, 72 (10). pp. 2419-2423. ISSN 0022-1317

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Abstract

In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.

Item Type:	Article
Uncontrolled Keywords:	virology ,/dk/atira/pure/subjectarea/asjc/2400/2406
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	08 Dec 2025 16:30
Last Modified:	18 Jun 2026 20:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101335
DOI:	10.1099/0022-1317-72-10-2419

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