In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy

Bell, J. D., Cox, I. J., Williams, S. C. R., Belton, P. S., McConnell, I. and Hope, J. (1991) In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy. Journal of General Virology, 72 (10). pp. 2419-2423. ISSN 0022-1317

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Abstract

In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.

Item Type:	Article
Uncontrolled Keywords:	virology ,/dk/atira/pure/subjectarea/asjc/2400/2406
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Dec 2025 16:30
Last Modified:	15 Dec 2025 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101335
DOI:	10.1099/0022-1317-72-10-2419

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