MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie

Chung, Yuen Li, Williams, Alun, Beech, John S., Williams, Steve C.R., Bell, Jimmy D., Cox, Jane I. and Hope, James (1995) MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie. Neurodegeneration, 4 (2). pp. 203-207. ISSN 1055-8330

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Abstract

Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.

Item Type:	Article
Uncontrolled Keywords:	blood-brain barrier,gd-dtpa,hamster model (263k),proton nuclear magnetic resonance imaging,scrapie,pathology and forensic medicine,neuropsychology and physiological psychology,clinical neurology ,/dk/atira/pure/subjectarea/asjc/2700/2734
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Dec 2025 16:30
Last Modified:	14 Dec 2025 07:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101328
DOI:	10.1006/neur.1995.0025

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