Brain bioenergetics in murine models of scrapie using in vivo 31P magnetic resonance spectroscopy

Chung, Yuen Li, Williams, Steve C.R., Hope, James and Bell, Jimmy D. (1999) Brain bioenergetics in murine models of scrapie using in vivo 31P magnetic resonance spectroscopy. NeuroReport, 10 (9). pp. 1899-1901. ISSN 0959-4965

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Abstract

The bioenergetic status of the brain in scrapie mouse models was investigated during the late, clinical phase of the disease, by in vivo phosphorus magnetic resonance spectroscopy (MRS). The only significant change observed in the scrapie-infected mice compared with controls was an increase in intracellular brain pH (7.20 ± 0.06 vs 7.10 ± 0.05). No other changes in energetic metabolism were observed in the infected mice beside a trend in the decrease of phosphomonoester (PME) level, possibly associated with an alteration in glycolytic intermediates. This study showed that even in the presence of severe cellular vacuolation and microglia infiltrate, cerebral bioenergetic is maintained.

Item Type:	Article
Uncontrolled Keywords:	adenosine triphosphate,in vivo,intracellular brain ph,phosphocreatine,phosphomonoester,phosphorus magnetic resonance spectroscopy,scrapie,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Dec 2025 16:30
Last Modified:	14 Dec 2025 07:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101323
DOI:	10.1097/00001756-199906230-00019

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