The shortest known prion protein gene allele occurs in goats, has only three octapeptide repeats and is non-pathogenic

Goldmann, Wilfred, Chong, Angela, Foster, James, Hope, James and Hunter, Nora (1998) The shortest known prion protein gene allele occurs in goats, has only three octapeptide repeats and is non-pathogenic. Journal of General Virology, 79 (12). pp. 3173-3176. ISSN 0022-1317

Full text not available from this repository. (Request a copy)

Abstract

The prion protein (PrP) gene modulates the incidence and incubation periods of transmissible spongiform encephalopathies of sheep, goats, mice and man. Here, a new caprine PrP allele encoding the shortest naturally occurring PrP protein so far described is reported. This variant contains only three instead of the usual five copies of a short peptide repeat [Pro-Gln/His-Gly-Gly-Gly-(Gly)-Trp-Gly-Gln] characteristic of PrP, with an additional Trp to Gly substitution in codon 102. Fifteen out of 111 genotyped goats carried the novel PrP allele and 14 survived without signs of disease for at least 4 years. One goat heterozygous for the polymorphism was challenged experimentally with SSBP/1-scrapie and succumbed after an unusually long incubation period.

Item Type:	Article
Uncontrolled Keywords:	virology ,/dk/atira/pure/subjectarea/asjc/2400/2406
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Dec 2025 16:30
Last Modified:	15 Dec 2025 01:19
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101316
DOI:	10.1099/0022-1317-79-12-3173

Actions (login required)

View Item