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ToolsKing, Oliver Spencer (2025) Synthesis of Mononuclear and Binuclear Silver(I) N-Heterocyclic Carbene Complexes for the Treatment of Breast Cancer. Doctoral thesis, University of East Anglia.
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Abstract
This thesis is concerned with the synthesis of novel mono- and binuclear Ag(I) N-heterocyclic carbene complexes and their utility as agents against breast cancer. The complexes were tested using in-vitro experiments to assess cell viabilities and activities, with additional studies to probe their possible mechanisms of action.
Chapter 1 Contains the background on cancer, metal-based chemotherapy, NHCs, synthesis of Ag(I)-NHC complexes and the current literature for their use against breast cancer. The project aims and complex design are also discussed.
Chapter 2 Outlines the synthesis and characterisation of bridged imidazolium salts and their corresponding binuclear Ag(I)-NHC complexes. The dynamics of the complexes were studied by variable temperature NMR spectroscopy and for some of the complexes crystal structures were analysed.
Chapter 3 Presents the synthesis and characterisation of both mono and binuclear derivatives of the complexes outlined in Chapter 2 and discusses challenges associated with the synthesis. The dynamics of the complexes were studied by variable temperature NMR and for some of the complexes crystal structures were analysed, for the Ag(I)-NHC complex [Ag2(L13)2](PF6)2 two conformers were obtained.
Chapter 4 Explores the stability, lipophilicity and cytotoxicity of the complexes that were described in Chapters 2 and 3. The p-fluoro derivatives were found to be the most active and selective of the complexes tested. For a smaller selection of the complexes mechanistic studies were undertaken.
Chapter 5 Expands work previously done by the group on vanadium β-diketonate complexes by exploring their chemistry with NHC ligands. The synthesis, characterisation and stability are discussed.
Chapter 6 Summarises the findings from the work carried out in this thesis and proposes future work and outlook.
Chapter 7 Contains the experimental, synthesis and characterisation data of the ligands and complexes described within this thesis and the procedures for the biological experiments.
| Item Type: | Thesis (Doctoral) |
|---|---|
| Faculty \ School: | Faculty of Science > School of Chemistry (former - to 2024) |
| Depositing User: | Chris White |
| Date Deposited: | 08 Dec 2025 15:11 |
| Last Modified: | 08 Dec 2025 15:11 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/101310 |
| DOI: |
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