Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

Chung, Yuen Li, Williams, Alun, Ritchie, Diane, Williams, Steve C.R., Changani, K. Kumar, Hope, James ORCID: https://orcid.org/0000-0003-2015-2389 and Bell, Jimmy D. (1999) Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases. NeuroReport, 10 (17). pp. 3471-3477. ISSN 0959-4965

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Abstract

MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data.

Item Type:	Article
Uncontrolled Keywords:	cjd,hamster,histopathology,magnetic resonance imaging,scrapie,general neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2800
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	05 Dec 2025 13:30
Last Modified:	18 Jun 2026 20:48
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101288
DOI:	10.1097/00001756-199911260-00002

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