Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

Chung, Yuen Li, Williams, Alun, Ritchie, Diane, Williams, Steve C.R., Changani, K. Kumar, Hope, James and Bell, Jimmy D. (1999) Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases. NeuroReport, 10 (17). pp. 3471-3477. ISSN 0959-4965

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Abstract

MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data.

Item Type:	Article
Uncontrolled Keywords:	cjd,hamster,histopathology,magnetic resonance imaging,scrapie,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	05 Dec 2025 13:30
Last Modified:	05 Dec 2025 13:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101288
DOI:	10.1097/00001756-199911260-00002

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