Expression of Polyubiquitin and Heat‐Shock Protein 70 Genes Increases in the Later Stages of Disease Progression in Scrapie‐Infected Mouse Brain

Kenward, Nigel, Hope, James, Landon, Michael and Mayer, R. John (1994) Expression of Polyubiquitin and Heat‐Shock Protein 70 Genes Increases in the Later Stages of Disease Progression in Scrapie‐Infected Mouse Brain. Journal of Neurochemistry, 62 (5). pp. 1870-1877. ISSN 0022-3042

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Abstract

Abstract: We have shown by northern analyses that the expression of the mouse polyubiquitin C gene is increased several fold in the brains of mice infected with both the ME7 and 87V strains of scrape. Expression of the polyubiquitin gene does not change significantly, compared with controls, until the later stages of disease progression when there is a 2.5‐fold increase in ME7‐infected brains and a 1.8‐fold increase in 87V‐infected brains. The patterns of changes of expression of the polyubiquitin genes in brains infected with the two strains of scrapie resemble those of accumulation of ubiquitin‐conjugate‐positive structures in the brain that are detected immunohisto chemically. A similar increase in the expression of a heatshock protein 70 gene also occurs.

Item Type:	Article
Uncontrolled Keywords:	gene expression,heat‐shock protein 70,prion disease,scrapie,ubiquitin,biochemistry,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	02 Dec 2025 15:30
Last Modified:	08 Dec 2025 12:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101186
DOI:	10.1046/j.1471-4159.1994.62051870.x

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