Natural scrapie in British sheep:breeds, ages and PrP gene polymorphisms.

Hunter, N., Foster, J. D. and Hope, J. (1992) Natural scrapie in British sheep:breeds, ages and PrP gene polymorphisms. The Veterinary Record, 130 (18). pp. 389-392. ISSN 0042-4900

Full text not available from this repository. (Request a copy)

Abstract

One hundred and sixty-seven sheep of 32 breeds and crossbreeds affected by natural scrapie throughout Britain were tested for the presence of restriction fragment length polymorphisms of the PrP gene observed when their DNA was digested with EcoRI or HindIII. These polymorphisms have already been associated with different susceptibilities to experimental scrapie (controlled by alleles of the Sip gene) in a flock of Cheviot sheep. In two studies 86 to 92 per cent of the sheep were found to carry the PrP gene EcoRI fragment e1 which is associated with high susceptibility (or the sA allele of Sip) to experimental scrapie. The PrP gene HindIII genotypes of the natural scrapie sheep were not apparently associated with differences in susceptibility to scrapie. There was no link between the polymorphisms and the age or breed of the affected sheep.

Item Type:	Article
Uncontrolled Keywords:	veterinary(all) ,/dk/atira/pure/subjectarea/asjc/3400
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	02 Dec 2025 15:30
Last Modified:	10 Dec 2025 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101180
DOI:	10.1136/vr.130.18.389

Actions (login required)

View Item