Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice

Hunter, Nora, Dann, Janine C., Bennett, Alan D., Somerville, Robert A., McConnell, Irene and Hope, James (1992) Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice. Journal of General Virology, 73 (10). pp. 2751-2755. ISSN 0022-1317

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Abstract

Congenic mouse strains VM/Dk and VM-Sinc(s7)/Dk differ at the Sinc gene, which controls the incubation period of scrapie in mice; VM/Dk mice are Sinc(p7p7) and VM-Sin(s7)/Dk mice are Sinc(s7s7). Restriction fragment length polymorphism and DNA sequencing analysis demonstrated that the PrP genes also differ in these strains, confirming the close genetic linkage of Sinc and PrP. Using the restriction enzyme HhaI, we have shown that at least 100 kb of DNA flanking the PrP gene differs between the two strains, and therefore the congruence of the Sinc and PrP genes is still not certain.

Item Type:	Article
Uncontrolled Keywords:	virology ,/dk/atira/pure/subjectarea/asjc/2400/2406
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	28 Nov 2025 11:30
Last Modified:	10 Dec 2025 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101147
DOI:	10.1099/0022-1317-73-10-2751

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