The impact of single nucleotide polymorphisms on the absorption, distribution, metabolism, and excretion of dietary (poly)phenols: a critical systematic review

Tosi, Nicole, Bragazzi, Nicola luigi, Mignogna, Cristiana, Treccani, Mirko, Bresciani, Letizia, Vauzour, David, Malerba, Giovanni, Barili, Valeria, Martorana, Davide, Del rio, Daniele and Mena, Pedro (2025) The impact of single nucleotide polymorphisms on the absorption, distribution, metabolism, and excretion of dietary (poly)phenols: a critical systematic review. Food & Function. ISSN 2042-6496

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Abstract

Response to (poly)phenol intake is highly variable among subjects, and genetic variants may contribute to such variability. However, evidence addressing this assumption is currently lacking. To address such shortcomings, we systematically reviewed the current literature and selected twelve studies looking at associations between the inter-individual variability in (poly)phenol bioavailability and metabolism and single nucleotide polymorphisms (SNPs) in candidate genes involved in (poly)phenol ADME (absorption, distribution, metabolism, and excretion). In total, 88 SNPs in 33 genes were studied, of which slightly more than half (n = 17) were related to drug/xenobiotic metabolism. More specifically, two were involved in absorption, seven in phase I metabolism, four in phase II metabolism, and four in excretion. The remaining 16 genes were related to steroid hormone metabolism and activity. Considering genes specifically related to (poly)phenol ADME, 16 SNPs showed significant modifying effects on urinary and/or plasma levels of phenolic metabolites and/or on their kinetic parameters. However, it was not possible to associate a particular genetic variant with a change in (poly)phenol-related ADME. Only a few studies applied stringent statistical criteria and recruited sufficiently large and diverse samples to reach solid and reliable conclusions. As such, studies employing larger samples, leveraging integrative bioinformatics approaches and genome-wide linkage, are warranted.

Item Type:	Article
Additional Information:	Data availability This article is a review and does not include new experimental data. All data cited and discussed in the manuscript are derived from previously published studies, which are appropriately referenced throughout the text. No new datasets were generated or analyzed during the preparation of this work. Supplementary information (SI) is available. See DOI: https://doi.org/10.1039/d5fo03349g.
Uncontrolled Keywords:	sdg 3 - good health and well-being,3* ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	20 Nov 2025 15:30
Last Modified:	20 Nov 2025 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101074
DOI:	10.1039/D5FO03349G

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