Technology, pharmacology, and clinical outcomes of sirolimus coated balloons for peripheral arterial interventions

Khonkarn, Ruttiros, Ramadani, Pranvera, Qi, Sheng ORCID: https://orcid.org/0000-0003-1872-9572, Ali, Tariq and Krokidis, Miltiadis (2025) Technology, pharmacology, and clinical outcomes of sirolimus coated balloons for peripheral arterial interventions. Expert Review of Medical Devices, 22 (12). pp. 1369-1378. ISSN 1745-2422

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Abstract

Introduction: Peripheral arterial intervention is a rapidly evolving field with a significant impact on an aging population. Areas covered: Treatment concepts evolve rapidly, with new therapies providing sustainable and cost-effective solutions for complex patients. Expert opinion: Metal stenting has been replaced by the ‘leave-nothing-behind’ approach, and plain balloon angioplasty devices have been replaced by drug-coated balloons (DCBs). While paclitaxel was initially used, sirolimus has more recently shown promising outcomes. This review article provides an overview of the technology and pharmacology behind sirolimus-coated balloons (SRL-DCB) and presents existing clinical evidence of their use.

Item Type:	Article
Uncontrolled Keywords:	peripheral vascular diseases,drug-coated balloons,restenosis,sirolimus,restenosis,peripheral vascular disease,drug-coated balloons,surgery,biomedical engineering ,/dk/atira/pure/subjectarea/asjc/2700/2746
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	28 Oct 2025 11:30
Last Modified:	18 Jun 2026 20:45
URI:	https://ueaeprints.uea.ac.uk/id/eprint/100813
DOI:	10.1080/17434440.2025.2574364

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