Technology, pharmacology, and clinical outcomes of sirolimus coated balloons for peripheral arterial interventions

Khonkarn, Ruttiros, Ramadani, Pranvera, Qi, Sheng, Ali, Tariq and Krokidis, Miltiadis (2025) Technology, pharmacology, and clinical outcomes of sirolimus coated balloons for peripheral arterial interventions. Expert Review of Medical Devices. ISSN 1745-2422

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Abstract

Introduction: Peripheral arterial intervention is a rapidly evolving field with a significant impact on an aging population. Areas covered: Treatment concepts evolve rapidly, with new therapies providing sustainable and cost-effective solutions for complex patients. Expert opinion: Metal stenting has been replaced by the ‘leave-nothing-behind’ approach, and plain balloon angioplasty devices have been replaced by drug-coated balloons (DCBs). While paclitaxel was initially used, sirolimus has more recently shown promising outcomes. This review article provides an overview of the technology and pharmacology behind sirolimus-coated balloons (SRL-DCB) and presents existing clinical evidence of their use.

Item Type:	Article
Uncontrolled Keywords:	peripheral vascular diseases,drug-coated balloons,restenosis,sirolimus,restenosis,peripheral vascular disease,drug-coated balloons,surgery,biomedical engineering ,/dk/atira/pure/subjectarea/asjc/2700/2746
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	28 Oct 2025 11:30
Last Modified:	28 Oct 2025 11:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/100813
DOI:	10.1080/17434440.2025.2574364

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