Tools
ToolsLeta, Valentina, Zinzalias, Pavlos, Batzu, Lucia, Mandal, Gargi, Staunton, Juliet, Jernstedt, Frida, Rosqvist, Kristina, Timpka, Jonathan, van Vliet, Trinette, Trivedi, Dhaval, Podlewska, Aleksandra, Parry, Miriam, van Wamelen, Daniel J., Rizos, Alexandra, Sportelli, Carolina, Bonder, Ana Laura, Chung-Faye, Guy, Falup-Pecurariu, Cristian, Gaisford, Simon, Moretto, Edoardo, Le Gall, Gwenaelle, Vauzour, David, Rodriguez-Mateos, Ana, Sauerbier, Anna, Rodriguez Blazquez, Carmen, Ghyselinck, Jonas, Marsaux, Benoît, Pariante, Carmine Maria, Borsini, Alessandra, Odin, Per and Ray Chaudhuri, Kallol (2025) Effects of a four-strain probiotic on gut microbiota, inflammation, and symptoms in Parkinson's disease: A randomized clinical trial. Movement Disorders. ISSN 0885-3185
Preview |
PDF (Movement Disorders - 2025 - Leta - Effects of a Four�Strain Probiotic on Gut Microbiota Inflammation and Symptoms in)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Background: Gut dysbiosis and gut-brain-axis involvement in people with Parkinson's disease (PwP) support the use of gut-microbiota-modulating interventions. Probiotics may help manage constipation in PwP; however, mechanisms underpinning additional beneficial properties are unknown. Objective: The aim was evaluating the effects of a probiotic (Lacticaseibacillus rhamnosus, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Enterococcus faecium) on gut microbiota, inflammation, motor and non-motor symptoms (NMS) in PwP and constipation. Methods: In this multicenter, randomized, double-blind, placebo-controlled trial (NCT05146921), PwP and constipation were randomized (1:1) to receive either the probiotic (4.08 × 108 CFU/mL) or placebo orally (70 mL/day) for 12 weeks. The primary endpoint was the differential abundance of gut microbiota taxa between baseline and end-of-treatment in the active versus placebo group. Secondary/exploratory endpoints included changes in inflammatory cytokines plasma levels, short-chain fatty acids (SCFAs) plasma and fecal levels, motor and NMS outcomes after 12 weeks. A per-protocol analysis was performed. Results: Between July 17, 2019 and February 6, 2022, 74 participants were randomized. Data from 35 (probiotic) and 33 (placebo) participants were analyzed. Enrichments of bacteria with beneficial health-related properties (Odoribacteraceae, Enterococcaceae, and Blautia faecicola) were observed in the active group compared to placebo (P ≤ 0.05). Proinflammatory cytokine TNF-α plasma levels decreased with probiotic treatment and increased with placebo (P < 0.05). No changes in SCFAs levels were observed. Reductions in time-to-on and NMS scale scores (P < 0.05) were observed only in the active group. Conclusions: This probiotic was effective in beneficially enriching the gut microbiota with potential to reduce systemic inflammation, shortening time-to-on following levodopa administration, and alleviating NMS burden in PwP experiencing constipation.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: The data that support the findings of this study are available on request from the corresponding authors and study sponsors. The data are not publicly available due to privacy or ethical restrictions. |
| Uncontrolled Keywords: | parkinson’s disease,gut microbiota,probiotics,inflammation;,motor symptoms,non-motor symptoms,sdg 3 - good health and well-being,4*,clinica study in pd patients with probiotics ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 24 Oct 2025 10:31 |
| Last Modified: | 24 Oct 2025 10:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/100754 |
| DOI: | 10.1002/mds.70047 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |