Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy

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Daniel, Olwenn, Srikanth, Sashank, Clarke, Paul, Le Doare, Kirsty, Heath, Paul T., Jones, Christine E., Scorrer, Tim, Snape, Matthew and Calvert, Anna (2025) Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy. Vaccine, 62. ISSN 0264-410X

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Abstract

The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).

Item Type: Article
Additional Information: Data availability: Data collected for the study, including individual (deidentified) participant data and a data dictionary defining each field in the set, can be made available for suitable applications submitted to the Chief Investigator (pheath@sgul.ac.uk). Additional related documents are available on request.
Uncontrolled Keywords: bordetella pertussis,immunoglobulin g,multiplex,preterm,serology,vaccine,molecular medicine,immunology and microbiology(all),veterinary(all),public health, environmental and occupational health,infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1313
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 11 Aug 2025 09:30
Last Modified: 13 Aug 2025 01:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/100119
DOI: 10.1016/j.vaccine.2025.127481

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