Can AI modeling of protein structures distinguish between sensor and helper NLR immune receptors?

Toghani, AmirAli; Frijters, Raoul; Bozkurt, Tolga O.; Terauchi, Ryohei; Kamoun, Sophien; Sugihara, Yu

doi:10.1111/nph.70391

Can AI modeling of protein structures distinguish between sensor and helper NLR immune receptors?

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Toghani, AmirAli, Frijters, Raoul, Bozkurt, Tolga O., Terauchi, Ryohei, Kamoun, Sophien ORCID: https://orcid.org/0000-0002-0290-0315 and Sugihara, Yu (2025) Can AI modeling of protein structures distinguish between sensor and helper NLR immune receptors? New Phytologist, 248 (1). pp. 17-23. ISSN 0028-646X

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Item Type:	Article
Additional Information:	The articulation of text within this manuscript was assisted by ChatGPT. Data availability: The scripts and dataset used for the phylogenetic analysis are available on GitHub (https://github.com/amiralito/Paired_NLR_AF3). The other datasets are archived on Zenodo (10.5281/zenodo.15552925). Funding information: The authors received funding from the sources listed below. The Gatsby Charitable Foundation (AT, SK, YS), Biotechnology and Biological Sciences Research Council (BBSRC) BB/P012574 (Plant Health ISP) (AT, SK, YS), BBSRC BBS/E/J/000PR9795 (Plant Health ISP – Recognition) (AT, SK, YS), BBSRC BBS/E/J/000PR9796 (Plant Health ISP – Response) (AT, SK, YS), BBSRC BBS/E/J/000PR9797 (Plant Health ISP – Susceptibility) (AT, SK, YS), BBSRC BBS/E/J/000PR9798 (Plant Health ISP – Evolution) (AT, SK, YS), BBSRC BB/X016382/1 (TOB), European Research Council (ERC) 743165 (SK), Engineering and Physical Sciences Research Council EP/Y032187/1 (SK), and Japan Society for the Promotion of Science (JSPS) 23K20042, 24H00010 (RT).
Uncontrolled Keywords:	alphafold,functional specialization,nlr immune receptor,plant–pathogen interactions,protein structure,physiology,plant science ,/dk/atira/pure/subjectarea/asjc/1300/1314
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory Faculty of Science > School of Biological Sciences
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	06 Aug 2025 16:30
Last Modified:	18 Jun 2026 20:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/100093
DOI:	10.1111/nph.70391

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