A Versatile Chiral Pyrrolidine Aldehyde Building-Block for Synthesis and Formal Synthesis of ent-Nakadomarin A

McDermott, Paul, Stockman, Robert A., Newton, Annabella F. and Magnus, Philip (2010) A Versatile Chiral Pyrrolidine Aldehyde Building-Block for Synthesis and Formal Synthesis of ent-Nakadomarin A. Synlett (4). pp. 559-562. ISSN 0936-5214

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Abstract

A stable, simple to synthesise and versatile chiral aldehyde building-block has been developed, its reactivity in Wittig, Horner-Wadsworth-Emmons and Grignard reactions investigated, and its use is demonstrated in a highly efficient synthesis of an intermediate in Dixon’s synthesis of nakadomarin A.

Item Type:	Article
Uncontrolled Keywords:	aldehyde - building-block - nakadomarin - manzamine
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
UEA Research Groups:	Faculty of Science > Research Groups > Innovations in Pharmacy Education
Depositing User:	LivePure Connector
Date Deposited:	04 Aug 2025 09:32
Last Modified:	11 Oct 2025 14:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/100043
DOI:	10.1055/s-0029-1219182

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