RNA polymerase IV directs silencing of endogenous DNA

Herr, A. J., Jensen, M. B., Dalmay, T. ORCID: https://orcid.org/0000-0003-1492-5429 and Baulcombe, D. C. (2005) RNA polymerase IV directs silencing of endogenous DNA. Science, 308 (5718). pp. 118-120. ISSN 0036-8075

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Abstract

Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:37
Last Modified:	06 Jun 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/955
DOI:	10.1126/science.1106910

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