Heparan sulfate as a regulator of inflammation and immunity

Collins, Laura E and Troeberg, Linda (2019) Heparan sulfate as a regulator of inflammation and immunity. Journal of Leukocyte Biology, 105 (1). pp. 81-92. ISSN 0741-5400

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    Heparan sulfate is found on the surface of most cell types, as well as in basement membranes and extracellular matrices. Its strong anionic properties and highly variable structure enable this glycosaminoglycan to provide binding sites for numerous protein ligands, including many soluble mediators of the immune system, and may promote or inhibit their activity. The formation of ligand binding sites on heparan sulfate (HS) occurs in a tissue- and context-specific fashion through the action of several families of enzymes, most of which have multiple isoforms with subtly different specificities. Changes in the expression levels of these biosynthetic enzymes occur in response to inflammatory stimuli, resulting in structurally different HS and acquisition or loss of binding sites for immune mediators. In this review, we discuss the multiple roles for HS in regulating immune responses, and the evidence for inflammation-associated changes to HS structure.

    Item Type: Article
    Additional Information: ©2018 Society for Leukocyte Biology.
    Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
    Related URLs:
    Depositing User: LivePure Connector
    Date Deposited: 08 Jan 2019 09:30
    Last Modified: 09 Apr 2019 14:02
    URI: https://ueaeprints.uea.ac.uk/id/eprint/69461
    DOI: 10.1002/JLB.3RU0618-246R

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