Comments on “Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense”

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Steverding, Dietmar (2020) Comments on “Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense”. Natural Product Research, 34 (6). pp. 751-753. ISSN 1478-6419

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Abstract

Recently, it was suggested that curcumin is an irreversible inhibitor of rhodesain, a cathepsin L-like cysteine protease found in the lysosome of the protozoan parasite Trypanosoma brucei. However, dilution of rhodesain incubated with curcumin with curcumin free buffer resulted in an immediate recovery of enzymatic activity. This finding clearly demonstrates that curcumin is in fact a reversible inhibitor of rhodesain.

Item Type:	Article
Uncontrolled Keywords:	analytical chemistry,biochemistry,plant science,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1602
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	13 Jul 2018 14:30
Last Modified:	21 Oct 2022 19:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/67627
DOI:	10.1080/14786419.2018.1500575

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