Interplay between metalloproteinases and cell signalling in blood brain barrier integrity

Pla-Navarro, Irene, Bevan, Damon, Hajihosseini, Mohammad K., Lee, Martin and Gavrilovic, Jelena (2018) Interplay between metalloproteinases and cell signalling in blood brain barrier integrity. Histology and Histopathology, 33. pp. 1253-1270. ISSN 0213-3911

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    Abstract

    The Blood-Brain Barrier (BBB) is a highly specialised interface separating the Central Nervous System (CNS) from circulating blood. Dysregulation of the BBB is a key early event in pathological conditions such as inflammation, in which the entry of activated leukocytes into the CNS is facilitated by BBB breakdown. The metzincin family of metalloproteinases (MPs) is one of the major contributors to BBB permeability as they cleave endothelial cell-cell contacts and underlying basal lamina components. However, the mechanisms by which MPs regulate BBB integrity has not yet been fully elucidated. The aim of this review is to provide an overview of pathways by which MPs could regulate the BBB in the context of neuroinflammation.

    Item Type: Article
    Uncontrolled Keywords: metalloproteinase,metzincin,blood-brain barrier,signalling pathway,neuroinflammation
    Faculty \ School: Faculty of Science > School of Biological Sciences
    Depositing User: Pure Connector
    Date Deposited: 17 May 2018 16:32
    Last Modified: 16 Jan 2019 01:10
    URI: https://ueaeprints.uea.ac.uk/id/eprint/67125
    DOI: 10.14670/HH-18-003

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