Vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy: a feasibility randomised controlled trial

Banerjee, Srijit, Manley, Kate, Shaw, Barnabas, Lewis, Liane, Cucato, Gabriel, Mills, Robert, Rochester, Mark, Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941 and Saxton, John (2018) Vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy: a feasibility randomised controlled trial. Journal of Supportive Care in Cancer, 26 (5). 1515–1523. ISSN 0941-4355

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Abstract

Purpose: Strategies to improve pre-operative cardiopulmonary fitness could positively impact recovery aftersurgery. This study investigated the feasibility of pre-operative vigorous intensity aerobic interval exercise inbladder cancer patients prior to radical cystectomy (RC). Methods: A total of 60 patients were randomised (1:1)to an exercise or control group following a cardiopulmonary exercise test (CPET). The exercise group wasoffered twice-weekly pre-operative supervised vigorous intensity aerobic interval exercise in addition tostandard treatment, whilst the controls received standard treatment only. A repeat CPET was undertaken beforesurgery and post-operative recovery outcomes were recorded. Results: Over half of the 112 eligible patientsapproached in the clinic were recruited to the study (53.5%), with 52 of the 60 recruited patients (87%)attending both pre-operative CPETs and post-operative recovery data being available for 55 of the patients(92%). Patients attended a median of 8 (range: 1-10) exercise sessions over a pre-operative period of 3-6 weeks.Improvements in peak values of oxygen pulse (P=0.001), minute ventilation (P=0.002) and power output(P<0.001) were observed at the follow-up CPET in the exercise group versus controls and there were no adverseevents. Although this feasibility study was not powered to detect changes in post-operative recovery outcomes,there were marginal (non-significant) differences in favour of the exercise group in post-operative Clavien-Dindo score and need for High Dependency Unit inotropic support. Conclusions: Vigorous intensity aerobicinterval exercise could be an effective strategy for improving pre-operative physiological reserve and postoperativerecovery outcomes in bladder cancer patients undergoing RC. Implications for Cancer Survivors:Bladder cancer patients respond well to pre-surgical interval exercise and the improvements in cardiopulmonaryfitness variables could have important implications for post-operative recuperation after RC.

Item Type:	Article
Uncontrolled Keywords:	pre-operative care,exercise ,urinary bladder neoplasms,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Allied Health Professions (former - to 2013)
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	Pure Connector
Date Deposited:	06 Dec 2017 06:07
Last Modified:	19 Oct 2023 02:06
URI:	https://ueaeprints.uea.ac.uk/id/eprint/65686
DOI:	10.1007/s00520-017-3991-2

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