The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling

Stegmann, Martin, Monaghan, Jacqueline, Smakowska-Luzan, Elwira, Rovenich, Hanna, Lehner, Anita, Holton, Nicholas, Belkhadir, Youssef and Zipfel, Cyril (2017) The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling. Science, 355 (6322). pp. 287-289. ISSN 0036-8075

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    Abstract

    In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold modulating receptor kinase complex assembly. A similar scaffolding mechanism may underlie RALF function in other signalling pathways.

    Item Type: Article
    Faculty \ School: Faculty of Science > School of Biological Sciences
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    Depositing User: Pure Connector
    Date Deposited: 17 Dec 2016 00:08
    Last Modified: 09 Apr 2019 11:48
    URI: https://ueaeprints.uea.ac.uk/id/eprint/61765
    DOI: 10.1126/science.aal2541

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