Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor

Harbord, M W N, Marks, D J B, Forbes, A, Bloom, S L, Day, R M and Segal, A W (2006) Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor. Alimentary Pharmacology and Therapeutics, 24 (4). pp. 651-60. ISSN 0269-2813

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Abstract

Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.

Item Type: Article
Uncontrolled Keywords: adult,aged,chemokines,chemotaxis, leukocyte,crohn disease,female,granulocyte colony-stimulating factor,humans,male,middle aged,neutrophils
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:46
Last Modified: 25 Jul 2018 09:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/49666
DOI: 10.1111/j.1365-2036.2006.03016.x

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