Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?

Polymeros, Dimitrios, Bogdanos, Dimitrios P, Day, Richard, Arioli, Dimitryi, Vergani, Diego and Forbes, Alastair (2006) Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease? Gastroenterology, 131 (1). pp. 85-96. ISSN 0016-5085

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Abstract

Most Crohn's disease (CD) patients show seroreactivity against Mycobacterium avium paratuberculosis (MAP), suggesting a pathogenic role for this organism. Our aim was to seek amino acid similarities between MAP and intestinal proteins that, through molecular mimicry, could serve as targets for cross-reactive immunity in CD.

Item Type: Article
Uncontrolled Keywords: adolescent,adult,aged,aged, 80 and over,antibody affinity,autoantigens,crohn disease,enzyme-linked immunosorbent assay,female,glutathione peroxidase,humans,male,middle aged,mycobacterium avium subsp. paratuberculosis,paratuberculosis,prognosis,severity of illness index
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:54
Last Modified: 11 Apr 2019 15:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/49661
DOI: 10.1053/j.gastro.2006.04.021

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