Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole

Bell, A J G, Nicholls, R J, Forbes, A, Ellis, H J and Ciclitira, P J (2004) Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole. Gut, 53 (12). pp. 1801-5. ISSN 0017-5749

Full text not available from this repository. (Request a copy)

Abstract

The gut flora may play an important role in the pathogenesis of inflammatory bowel disease. An ileal reservoir or pouch can be created to replace the excised rectum after proctocolectomy. In patients with ulcerative colitis this is subject to inflammation and termed pouchitis. Using bacteria from patients the authors sought evidence for the presence rather than the identity of a pathogenic species in pouchitis, and for its absence in healthy pouches by the differential effect on lymphocyte proliferation.

Item Type: Article
Uncontrolled Keywords: adolescent,adult,aged,anti-bacterial agents,bacteria,cell division,cells, cultured,colonic pouches,female,humans,lymphocyte activation,male,metronidazole,middle aged,pouchitis,sonication
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:36
Last Modified: 11 Apr 2019 15:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/49627
DOI: 10.1136/gut.2003.026807

Actions (login required)

View Item