The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability

Fairweather-Tait, Susan ORCID: https://orcid.org/0000-0002-1413-5569, Phillips, Ian, Wortley, Gary, Harvey, Linda and Glahn, Ray (2007) The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability. International Journal for Vitamin and Nutrition Research, 77 (3). pp. 158-165. ISSN 0300-9831

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Abstract

An update on in vitro methods employed to assess iron bioavailability is presented. Solubility and dialyzability are not useful predictors of iron absorption, whereas Caco-2 cell models provide useful comparisons on the availability of iron from different sources. Strengths and weaknesses of in vitro approaches are briefly described, including the need to characterize Caco-2 cells in order to interpret results correctly. Further developments are required to refine Caco-2 model systems, including optimization and standardization of methods.

Item Type:	Article
Uncontrolled Keywords:	biological availability,caco-2 cells,dialysis,humans,intestinal absorption,iron, dietary,models, biological,predictive value of tests,solubility
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	29 Jul 2014 12:22
Last Modified:	19 Oct 2023 01:18
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49131
DOI:	10.1024/0300-9831.77.3.158

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