The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability

Fairweather-Tait, Susan, Phillips, Ian, Wortley, Gary, Harvey, Linda and Glahn, Ray (2007) The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability. International Journal for Vitamin and Nutrition Research, 77 (3). pp. 158-65. ISSN 0300-9831

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Abstract

An update on in vitro methods employed to assess iron bioavailability is presented. Solubility and dialyzability are not useful predictors of iron absorption, whereas Caco-2 cell models provide useful comparisons on the availability of iron from different sources. Strengths and weaknesses of in vitro approaches are briefly described, including the need to characterize Caco-2 cells in order to interpret results correctly. Further developments are required to refine Caco-2 model systems, including optimization and standardization of methods.

Item Type: Article
Uncontrolled Keywords: biological availability,caco-2 cells,dialysis,humans,intestinal absorption,iron, dietary,models, biological,predictive value of tests,solubility
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
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Depositing User: Pure Connector
Date Deposited: 29 Jul 2014 13:22
Last Modified: 25 Jul 2018 09:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/49131
DOI: 10.1024/0300-9831.77.3.158

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