Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response

Bouwens, Mark, Afman, Lydia A and Müller, Michael (2008) Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response. BMC Genomics, 9. ISSN 1471-2164

Full text not available from this repository. (Request a copy)

Abstract

Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person. Recently, we showed that the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) has a functional role in human PBMCs during fasting. However, the extent of the role of PPARalpha in human PBMCs remains unclear. In this study, we therefore performed gene expression profiling of PBMCs incubated with the specific PPARalpha ligand WY14,643.

Item Type: Article
Uncontrolled Keywords: amino acids,fasting,fatty acids,gene expression profiling,gene expression regulation,genome, human,humans,hypolipidemic agents,leukocytes, mononuclear,oligonucleotide array sequence analysis,ppar alpha,pyrimidines,response elements
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 21 Feb 2014 11:32
Last Modified: 25 Jul 2018 09:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/47707
DOI: 10.1186/1471-2164-9-262

Actions (login required)

View Item