Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro

Barrera, Lawrence N, Johnson, Ian T, Bao, Yongping, Cassidy, Aedin and Belshaw, Nigel J (2013) Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro. European Journal of Nutrition, 52 (4). pp. 1327-41.

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Abstract

It is relatively unknown how different dietary components, in partnership, regulate gene expression linked to colon pathology. It has been suggested that the combination of various bioactive components present in a plant-based diet is crucial for their potential anticancer activities. This study employed a combinatorial chemopreventive strategy to investigate the impact of selenium and/or isothiocyanates on DNA methylation processes in colorectal carcinoma cell lines.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
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University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Epidemiology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 20 Aug 2013 06:28
Last Modified: 25 Jul 2018 08:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/43132
DOI: 10.1007/s00394-012-0442-1

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