Efficacy of memantine for agitation in Alzheimer's dementia:a randomised double-blind placebo controlled trial

Fox, Chris, Crugel, Monica, Maidment, Ian, Auestad, Bjorn Henrik, Coulton, Simon, Treloar, Adrian, Ballard, Clive, Boustani, Malaz, Katona, Cornelius and Livingston, Gill (2012) Efficacy of memantine for agitation in Alzheimer's dementia:a randomised double-blind placebo controlled trial. PLoS ONE, 7 (5). ISSN 1932-6203

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Abstract

Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. We tested the primary hypothesis, memantine is superior to placebo for clinically significant agitation, in patients with moderate-to-severe AD.

Item Type: Article
Uncontrolled Keywords: aged,aged, 80 and over,alzheimer disease,dementia,female,humans,male,memantine,psychomotor agitation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Deborah Clemitshaw
Date Deposited: 11 Sep 2012 13:17
Last Modified: 20 Dec 2018 14:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/39514
DOI: 10.1371/journal.pone.0035185

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