Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci

Livermore, DM, Mushtaq, S., Warner, M. and Woodford, N. (2009) Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci. Journal of Antimicrobial Chemotherapy, 63 (4). pp. 713-715. ISSN 0305-7453

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Abstract

Background TR-700 is the active moiety of TR-701 (DA-7157), a new oral/intravenous oxazolidinone prodrug. We examined its activity against linezolid-susceptible and -resistant staphylococci and enterococci. Methods MICs were determined by the CLSI agar dilution method. Results MICs of TR-700 were tightly clustered around 0.5 mg/L for linezolid-susceptible staphylococci and enterococci compared with 2 mg/L for linezolid. MICs for 52 linezolid-resistant isolates were raised, but only exceeded 4 mg/L for two Enterococcus faecium isolates homozygous for the G2576T 23S rRNA mutation and for one with an unknown mechanism of linezolid resistance. Conclusions TR-700 is 4- to 16-fold more active than linezolid and overcame most linezolid resistance in vitro.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Rhiannon Harvey
Date Deposited: 05 Jul 2011 12:14
Last Modified: 23 Jan 2019 13:35
URI: https://ueaeprints.uea.ac.uk/id/eprint/33354
DOI: 10.1093/jac/dkp002

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