Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system.

Meader, Emma, Mayer, Melinda J, Gasson, Michael J, Steverding, Dietmar, Carding, Simon R and Narbad, Arjan (2010) Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system. Anaerobe, 16 (6). pp. 549-54. ISSN 1095-8274

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Abstract

Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p =

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 04 Apr 2011 19:43
Last Modified: 21 Mar 2019 10:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/27980
DOI:

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