Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?

Friščić, Tomislav, Fabian, Laszlo, Burley, Jonathan C., Reid, David G., Duer, Melinda J. and Jones, William (2008) Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids? Chemical Communications (14). p. 1644. ISSN 1364-548X

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Abstract

Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
University of East Anglia > Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials
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Depositing User: Rachel Smith
Date Deposited: 15 Mar 2011 15:10
Last Modified: 25 Jul 2018 05:12
URI: https://ueaeprints.uea.ac.uk/id/eprint/26269
DOI: 10.1039/b717532a

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