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Number of items at this level: 131.

A

Antelmann, H and Hamilton, CJ (2012) Bacterial mechanisms of reversible protein S-thiolation: structural and mechanistic insights into mycoredoxins. Molecular Microbiology, 86 (4). pp. 759-764. ISSN 1365-2958

Anwar, Awais, Gould, Emma, Tinson, Ryan, Groom, Murree and Hamilton, Chris J. (2016) Think Yellow and Keep Green—Role of Sulfanes from Garlic in Agriculture. Antioxidants, 6 (1). ISSN 2076-3921

Armer, RE, Cowley, P and Searcey, M (2008) Recent disclosures of clinical drug candidates. Drug News & Perspectives, 21 (3). pp. 183-8. ISSN 0214-0934

B

Banoz-Sanz, JI, Sanz-Aparicio, J, Whitfield, H, Hamilton, Christopher, Brearley, CA and Gonzalez, B (2012) Conformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding:Role of N-terminal lobe and enantiomeric substrate preference. The Journal of Biological Chemistry, 287 (35). pp. 29237-29249. ISSN 1083-351X

Bertrand, Benoît, Fernandez-Cestau, Julio, Angulo, Jesus, Cominetti, Marco M.D., Waller, Zoe A.E., Searcey, Mark, O'Connell, Maria A. and Bochmann, Manfred (2017) Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties. Inorganic Chemistry, 56 (10). 5728–5740. ISSN 0020-1669

Bonnet, D, Margathe, JF, Radford, S, Pflimlin, E, Riche, S, Doman, P, Hibert, M and Ganesan, A (2012) Combinational aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP). ACS Combinatorial Science, 14. pp. 323-334. ISSN 2156-8952

Bouthenet, E, Oh, K-B, Park, S, Nagi, NK, Lee, H-S and Matthews, SE (2011) Synthesis and antimicrobial activity of brominated resorcinol dimers. Bioorganic & Medicinal Chemistry Letters, 23 (23). pp. 7142-7145. ISSN 1464-3405

Brissonnet, Yoan, Ortiz Mellet, Carmen, Morandat, Sandrine, Garcia Moreno, M. Isabel, Deniaud, David, Matthews, Susan, Vidal, Sebastien, Sestak, Sergej, El Kirat, Karim and Gouin, Sebastien G (2013) Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases. Journal of the American Chemical Society, 135 (49). pp. 18427-18435. ISSN 0002-7863

Brogden, A. L., Hopcroft, N. H., Searcey, M. and Cardin, C. J. (2007) Ligand bridging of the DNA Holliday junction: Molecular recognition of a stacked-X four-way junction by a small molecule. Angewandte Chemie-International Edition, 46 (21). pp. 3850-3854. ISSN 1433-7851

Buffet, Kevin, Nierengarten, Iwona, Galanos, Nicolas, Gillon, Emilie, Holler, Michel, Imberty, Anne, Matthews, Susan E., Vidal, Sébastien, Vincent, Stéphane P. and Nierengarten, Jean-François (2016) Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectins. Chemistry - A European Journal, 22 (9). pp. 2955-2963. ISSN 0947-6539

Busnelli, Marta, Kleinau, Gunnar, Muttenthaler, Markus, Stoev, Stoytcho, Manning, Maurice, Bibic, Lucka, Howell, Lesley A., McCormick, Peter J., Di Lascio, Simona, Braida, Daniela, Sala, Mariaelvina, Rovati, G. Enrico, Bellini, Tommaso and Chini, Bice (2016) Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure. Journal of Medicinal Chemistry, 59 (15). 7152–7166. ISSN 0022-2623

C

Casely-Hayford, M. A., Kerr, N. O, Smith, E., Gibbons, S. and Searcey, M. (2005) Antitumour antibiotics with potent activity against multidrug resistant (MDR) Staphylococcus aureus: a new approach to targeting resistant bacteria. Med Chem, 1 (6). pp. 619-627. ISSN 1573-4064

Casely-Hayford, M. A., Pors, K., James, C. H., Patterson, L. H., Hartley, J. A. and Searcey, M. (2005) Design and synthesis of a DNA-crosslinking azinomycin analogue. Organic & Biomolecular Chemistry, 3 (19). pp. 3585-3589. ISSN 1477-0520

Casely-Hayford, M. A., Pors, K., Patterson, L. H., Gerner, C., Neidle, S. and Searcey, M. (2005) Truncated azinomycin analogues intercalate into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 653-656. ISSN 0960-894X

Cecioni, Samy, Lalor, Ruth, Blanchard, Bertrand, Praly, Jean-Pierre, Imberty, Anne, Matthews, Susan E and Vidal, Sebastien (2009) Achieving High Affinity towards a Bacterial Lectin through Multivalent Topological Isomers of Calix[4]arene Glycoconjugates. Chemistry - A European Journal, 15 (47). pp. 13232-13240. ISSN 0947-6539

Cecioni, Samy, Matthews, SE, Blanchard, Helen, Praly, Jean-Pierre, Imberty, Anne and Vidal, Sébastien (2012) Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins. Carbohydrate Research, 356. pp. 132-141. ISSN 1873-426X

Chandrangsu, Pete, Dusi, Renata, Hamilton, Chris J. and Helmann, John D. (2014) Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways. Molecular Microbiology, 91 (4). pp. 706-715. ISSN 0950-382X

Chi, Bui Khanh, Roberts, Alexandra A., Huyen, Tran Thi Thanh, Bäsell, Katrin, Becher, Dörte, Albrecht, Dirk, Hamilton, Chris J. and Antelmann, Haike (2013) S-Bacillithiolation Protects Conserved and Essential Proteins Against Hypochlorite Stress in Firmicutes Bacteria. Antioxidants & Redox Signaling, 18 (11). pp. 1273-1295. ISSN 1523-0864

Clark, Ryan C., Lee, Sang Yeul, Hwang, Inkyu, Searcey, Mark and Boger, Dale L. (2009) Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues. Tetrahedron Letters, 50 (26). pp. 3151-3153.

Clark, Ryan C., Lee, Sang Yeul, Searcey, Mark and Boger, Dale L. (2009) The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction. Natural Product Reports, 26 (4). p. 465.

Collingwood, S., Lock, R. and Searcey, Mark (2009) Optimizing drugs for local delivery. Drug News & Perspectives, 22 (10). pp. 627-634. ISSN 0214-0934

D

Dash, Jyotirmayee, Waller, Z.A.E., Pantoş, G. Dan and Balasubramanian, Shankar (2011) Synthesis and Binding Studies of Novel Diethynyl-Pyridine Amides with Genomic Promoter DNA G-Quadruplexes. Chemistry - A European Journal, 17 (16). 4571–4581. ISSN 0947-6539

David-Cordonnier, M. H., Casely-Hayford, M., Kouach, M., Briand, G., Patterson, L. H., Bailly, C. and Searcey, M. (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). 1658–1661. ISSN 1439-4227

Davidson, Sean M., Foote, Kirsty, Kunuthur, Suma, Gosain, Raj, Tan, Noah, Tyser, Richard, Zhao, Yong Juan, Graeff, Richard, Ganesan, A., Duchen, Michael R., Patel, Sandip and Yellon, Derek M. (2016) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovascular Research, 108 (3). pp. 357-366. ISSN 0008-6363

Dawson, S., Malkinson, J. P., Paumier, D. and Searcey, M. (2007) Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies. Natural Product Reports, 24 (1). pp. 109-126. ISSN 0265-0568

Day, Henry A, Pavlou, Pavlos and Waller, Zoë A E (2014) i-Motif DNA:Structure, stability and targeting with ligands. Bioorganic & Medicinal Chemistry, 22 (16). 4407–4418. ISSN 0968-0896

Day, Henry A., Huguin, Camille and Waller, Z.A.E. (2013) Silver cations fold i-motif at neutral pH. Chemical Communications, 49 (70). p. 7696. ISSN 1359-7345

E

Evans, A. J., Matthews, S. E., Cowley, A. R. and Beer, P. D. (2003) Anion binding by calix[4]arene ferrocene ureas. Dalton Transactions (24). pp. 4644-4650. ISSN 1477-9226

F

Felix, V., Matthews, S. E., Beer, P. D. and Drew, M. G. B. (2002) Selectivity of calix[4]tubes towards metal ions: A molecular dynamics study. Physical Chemistry Chemical Physics, 4 (15). pp. 3849-3858. ISSN 1463-9076

G

Gaballa, Ahmed, Chi, Bui Khanh, Roberts, Alexandra A., Becher, Dörte, Hamilton, Christopher, Antelmann, Haike and Helmann, John D. (2014) Redox Regulation in Bacillus subtilis : The Bacilliredoxins BrxA(YphP) and BrxB(YqiW) Function in De-bacillithiolation of S -Bacillithiolated OhrR and MetE. Antioxidants & Redox Signaling, 21 (3). pp. 357-367. ISSN 1523-0864

Galanos, Nicolas, Gillon, Emilie, Imberty, Anne, Matthews, Susan and Vidal, Sebastien (2016) Pentavalent pillar[5]arene-based glycoclusters and their multivalent binding to pathogenic bacterial lectins. Organic & Biomolecular Chemistry, 14. pp. 3476-3481. ISSN 1477-0520

Gallacher, G, Jackson, C S, Searcey, Mark, Badman, G T, Goel, R, Topham, C M, Mellor, G W and Brocklehurst, K (1991) A polyclonal antibody preparation with Michaelian catalytic properties. Biochemical Journal, 279 ( Pt 3). pp. 871-81. ISSN 0264-6021

Gallacher, G, Jackson, C S, Searcey, Mark, Goel, R, Mellor, G W, Smith, C Z and Brocklehurst, K (1993) Catalytic antibody activity elicited by active immunisation. Evidence for natural variation involving preferential stabilization of the transition state. European Journal of Biochemistry, 214 (1). pp. 197-207. ISSN 0014-2956

Gallacher, G, Jackson, C S, Topham, C M, Searcey, Mark, Turner, B C, Badman, G T and Brocklehurst, K (1990) Polyclonal-antibody-catalysed hydrolysis of an aryl nitrophenyl carbonate. Biochemical Society Transactions, 18 (4). pp. 600-601. ISSN 0300-5127

Gallacher, G, Searcey, Mark, Jackson, C S and Brocklehurst, K (1992) Polyclonal antibody-catalysed amide hydrolysis. Biochemical Journal, 284 ( Pt 3). pp. 675-860. ISSN 0264-6021

Ganesan, A (2008) The impact of natural products upon modern drug discovery. Current Opinion in Chemical Biology, 12 (3). pp. 306-317. ISSN 1879-0402

Ganesan, A, Nolan, L, Crabb, SJ and Packham, G (2009) Epigenetic Therapy: Histone Acetylation, DNA Methylation and Anti-Cancer Drug Discovery. Current Cancer Drug Targets, 9 (8). pp. 963-981. ISSN 1568-0096

Ganesan, A. (2016) Multitarget Drugs: an Epigenetic Epiphany. ChemMedChem, 11 (12). pp. 1227-1241. ISSN 1860-7179

Ghosh, N., Sheldrake, H. M., Searcey, M. and Pors, K. (2009) Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products. Current Topics in Medicinal Chemistry, 9 (16). pp. 1494-1524. ISSN 1568-0266

H

Hamilton, C. J. (2004) Enzymes in preparative mono- and oligo-saccharide synthesis. Natural Product Reports, 21 (3). pp. 365-385. ISSN 0265-0568

Hamilton, C. J., Fairlamb, A. H. and Eggleston, I. M. (2002) Regiocontrolled synthesis of the macrocyclic polyamine alkaloid (+/-)-lunarine, a time-dependent inhibitor of trypanothione reductase. Journal of the Chemical Society, Perkin Transactions 1 (8). pp. 1115-1123. ISSN 1472-7781

Hamilton, C. J., Saravanamuthu, A., Eggleston, I. M. and Fairlamb, A. H. (2003) Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate economical microplate and time-dependent inhibition assays for trypanothione reductase. Biochemical Journal, 369. pp. 529-537. ISSN 0264-6021

Hamilton, C. J., Saravanamuthu, A., Fairlamb, A. H. and Eggleston, I. M. (2003) Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase. Bioorganic & Medicinal Chemistry, 11 (17). pp. 3683-3693. ISSN 0968-0896

Hamilton, C. J., Saravanamuthu, A., Poupat, C., Fairlamb, A. H. and Eggleston, I. M. (2006) Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products. Bioorganic & Medicinal Chemistry, 14 (7). pp. 2266-2278. ISSN 0968-0896

Hamilton, Chris J. and Roberts, Stanley M. (1999) Synthesis of fluorinated phosphonoacetate derivatives of carbocyclic nucleoside monophosphonates and activity as inhibitors of HIV reverse transcriptase. Journal of the Chemical Society, Perkin Transactions 1 (8). pp. 1051-1056. ISSN 1472-7781

Hamilton, Chris J., Roberts, Stanley M. and Shipitsin, Alexander (1998) Synthesis of a potent inhibitor of HIV reverse transcriptase. Chemical Communications (10). pp. 1087-1088. ISSN 1359-7345

Hamon, Mélanie, Dickinson, Niall, Devineau, Alice, Bolien, David, Tranchant, Marie-josé, Taillier, Catherine, Jabin, Ivan, Harrowven, David C., Whitby, Richard J., Ganesan, A. and Dalla, Vincent (2014) Intra- and Intermolecular Alkylation of N , O -Acetals and π-Activated Alcohols Catalyzed by in Situ Generated Acid. Journal of Organic Chemistry, 79 (5). pp. 1900-1912. ISSN 0022-3263

Hampshire, Andrew J., Rusling, David A., Bryan, Stephanie, Paumier, David, Dawson, Simon J., Malkinson, John P., Searcey, Mark and Fox, Keith R. (2008) DNA Binding by Analogues of the Bifunctional Intercalator TANDEM. Biochemistry, 47 (30). pp. 7900-7906.

Hopcroft, N. H., Brogden, A. L., Searcey, M. and Cardin, C. J. (2006) X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)(2) molecules by a bis(9-aminoacridine-4-carboxamide) derivative. Nucleic Acids Research, 34 (22). pp. 6663-6672. ISSN 0305-1048

Howell, LA, Waller, Z.A.E., Bowater, RP, O'Connell, M and Searcey, M (2011) A small molecule that induces assembly of a four way DNA junction at low temperature. Chemical Communications, 47 (29). pp. 8262-8264. ISSN 1359-7345

Howell, Lesley, Gulam, R, Mueller, Anja, O'Connell, Maria and Searcey, Mark (2010) Design and synthesis of threading intercalators to target DNA. Bioorganic & Medicinal Chemistry Letters, 1 (20). pp. 6956-6959. ISSN 1464-3405

Howell, Lesley, Howman, Aaron, O'Connell, Maria, Mueller, Anja and Searcey, Mark (2009) Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. Bioorganic & Medicinal Chemistry Letters, 19 (20). pp. 5880-5883. ISSN 1464-3405

Howell, Lesley and Searcey, Mark (2009) Targeting Higher-Order DNA: Beyond the G-Quadruplex. ChemBioChem, 10 (13). pp. 2139-2143. ISSN 1439-7633

Howell, Lesley A., Bowater, Richard A., O'Connell, Maria A., Reszka, Anthony P., Neidle, Stephen and Searcey, Mark (2012) Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry. ChemMedChem, 7 (5). pp. 792-804. ISSN 1860-7179

I

Iijima, Y, Munakata, A, Shin-ya, K, Ganesan, A, Doi, T and Takahashi, T (2009) A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A. Tetrahedron Letters, 50 (24). pp. 2970-2972.

Iqbal, Amjid, Chibli, Hicham and Hamilton, Christopher (2013) Stability of aminooxy glycosides to glycosidase catalysed hydrolysis. Carbohydrate Research, 377. pp. 1-3. ISSN 0008-6215

Izumi, M, Kido, T, Murakami, M, Nakajima, S and Ganesan, A (2011) Pictet-Spengler Reaction Using Ion-Exchange Resin as a Catalyst and Support for ‘Catch and Release’ Purification. Bioscience, Biotechnology, and Biochemistry, 75 (2). pp. 391-392. ISSN 0916-8451

J

Jothivasan, V. K. and Hamilton, C. J. (2008) Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes. Natural Product Reports, 25 (6). pp. 1091-1117. ISSN 0265-0568

K

Kim, Jong-Seung, Park, Sun-Young, Kim, Sang-Hoon, Thuery, Pierre, Souane, Rachid, Matthews, Susan E and Vicens, Jacques (2010) A Pyrenyl-Appended Triazole-Based Calix[4]arene as a Fluorescent Sensor for Iodide Ion. Bulletin of the Korean Chemical Society, 31 (3). pp. 624-629. ISSN 0253-2964

L

Lall, Namrita, Kumar, Vivek, Meyer, Debra, Gasa, Nomasomi, Hamilton, Chris, Matsabisa, Motlalepula and Oosthuizen, Carel (2016) In vitro and In vivo antimycobacterial, hepatoprotective and immunomodulatory activity of Euclea natalensis and its mode of action. Journal of Ethnopharmacology, 194. 740–748. ISSN 0378-8741

Li, Min, Luo, Bingling, Liu, Qi, Hu, Yumin, Ganesan, A., Huang, Peng and Wen, Shijun (2014) Synthesis of N -Acyl- N , O -acetals Mediated by Titanium Ethoxide. Organic Letters, 16 (1). pp. 10-13. ISSN 1523-7060

Lincheneau, C., Quinlan, E., Kitchen, J.A., McCabe, T., Matthews, Susan and Gunnlaugsson, T. (2013) Delayed lanthanide luminescent Tb(III) complexes formed from lower rim amide functionalised calix[4]arenes. Supramolecular Chemistry, 25 (12). pp. 869-880. ISSN 1061-0278

Luan, Hemi, Meng, Nan, Fu, Jin, Chen, Xiaomin, Xu, Xun, Feng, Qiang, Jiang, Hui, Dai, Jun, Yuan, Xune, Lu, Yanping, Roberts, Alexandra A., Luo, Xiao, Chen, Maoshan, Xu, Shengtao, Li, Jun, Hamilton, Christopher, Fang, Chengxiang and Wang, Jun (2014) Genome-Wide Transcriptome and Antioxidant Analyses on Gamma-Irradiated Phases of Deinococcus radiodurans R1. PLoS ONE, 9 (1). ISSN 1932-6203

M

Mahapatra, A., Mativandlela, S. P. N., Binneman, B., Fourie, P. B., Hamilton, C. J., Meyer, J. J. M., van der Kooy, F., Houghton, P. and Lall, N. (2007) Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase. Bioorganic & Medicinal Chemistry, 15 (24). pp. 7638-7646. ISSN 0968-0896

Malkinson, J. P., Zloh, M., Kadom, M., Errington, R., Smith, P. J. and Searcey, M. (2003) Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions. Organic Letters, 5 (26). pp. 5051-5054. ISSN 1523-7060

Marin, MJ, Rackham, Benjamin D., Round, Andrew N., Howell, Lesley A., Russell, David A. and Searcey, Mark (2013) A rapid screen for molecules that form duplex to duplex crosslinks in DNA. Chemical Communications, 49 (80). p. 9113. ISSN 1359-7345

Mativandiela, S. P. N., Meyer, J. J. M., Hussein, A. A., Houghton, P. J., Hamilton, C. J. and Lall, N. (2008) Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants. Phytotherapy Research, 22 (6). pp. 841-845. ISSN 0951-418X

Matthews, S. E. and Beer, P. D. (2005) Calixarene-based anion receptors. Supramolecular Chemistry, 17 (6). pp. 411-435. ISSN 1061-0278

Matthews, S. E., Felix, V., Drew, M. G. B. and Beer, P. D. (2003) Halo-derivatised calix[4]tubes. Organic & Biomolecular Chemistry, 1 (7). pp. 1232-1239. ISSN 1477-0520

Matthews, S. E., Felix, V., Drew, M. G. B. and Beer, P. D. (2001) Thiacalix[4]tube: synthesis, X-ray crystal structure and preliminary binding studies. New Journal of Chemistry, 25 (11). pp. 1355-1358. ISSN 1144-0546

Matthews, S. E., Rees, N. H., Felix, F., Drew, M. G. B. and Beer, P. D. (2003) Thallium pi-cation complexation by calix[4]tubes: Tl-205 NMR and X-ray evidence. Inorganic Chemistry, 42 (3). pp. 729-734. ISSN 0020-1669

Matthews, S. E., Schmitt, P., Felix, V., Drew, M. G. B. and Beer, P. D. (2002) Calix[4]tubes: A new class of potassium-selective ionophore. Journal of the American Chemical Society, 124 (7). pp. 1341-1353. ISSN 0002-7863

McClean, S, Costelloe, C, Denny, W A, Searcey, Mark and Wakelin, L P (1999) Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards. Anti-Cancer Drug Design, 14 (3). pp. 187-204. ISSN 0266-9536

McLuckie, Keith I. E., Waller, Z.A.E., Sanders, Deborah A., Alves, David, Rodriguez, Raphaël, Dash, Jyotirmayee, McKenzie, Grahame J., Venkitaraman, Ashok R. and Balasubramanian, Shankar (2011) G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells. Journal of the American Chemical Society, 133 (8). pp. 2658-2663.

Moore, D. and Matthews, S. E. (2009) O-alkyl resorcarenes: where are we now? Journal of Inclusion Phenomena and Macrocyclic Chemistry, 65 (1-2). pp. 137-155. ISSN 0923-0750

Moore, Deborah, Watson, Graeme W., Gunnlaugsson, Thorfinnur and Matthews, Susan E (2008) Selective formation of the rctt chair stereoisomers of octa-O-alkyl resorcin[4]arenes using Brønsted acid catalysis. New Journal of Chemistry, 32 (6). p. 994. ISSN 1369-9261

Moore, M. J. B., Cuenca, F., Searcey, M. and Neidle, S. (2006) Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Organic & Biomolecular Chemistry, 4 (18). pp. 3479-3488. ISSN 1477-0520

N

Naylor, E, Arredouani, A, Vasudevan, SR, Lewis, AM, Parkesh, R, Mizote, A, Rosen, D, Thomas, JM, Izumi, M, Ganesan, A, Galione, A and Churchill, GC (2009) Identification of a chemical probe for NAADP by virtual screening. Nature Chemical Biology, 5 (4). pp. 220-226. ISSN 1552-4450

O

Oosthuizen, Carel, Arbach, Miriam, Meyer, Debra, Hamilton, Chris and Lall, Namrita (2017) Diallyl Polysulfides from Allium sativum as Immunomodulators, Hepatoprotectors, and Antimycobacterial Agents. Journal of Medicinal Food, 20 (7). pp. 685-690. ISSN 1096-620X

P

Park, Sun Young, Yoon, Jung Hee, Hong, Chang Seop, Souane, Rachid, Kim, Jong Seung, Matthews, Susan E and Vicens, Jacques (2008) A Pyrenyl-Appended Triazole-Based Calix[4]arene as a Fluorescent Sensor for Cd2+and Zn2+. The Journal of Organic Chemistry, 73 (21). pp. 8212-8218.

Parsonage, Derek, Newton, Gerald L., Holder, Robert C., Wallace, Bret D., Paige, Carleitta, Hamilton, Christopher, Dos Santos, Patricia C., Redinbo, Matthew R., Reid, Sean D. and Claiborne, Al (2010) Characterization of the N-Acetyl-α-d-glucosaminyll-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis. Biochemistry, 49 (38). pp. 8398-8414.

Pors, K., Plumb, J. A., Brown, R., Teesdale-Spittle, P., Searcey, M., Smith, P. J. and Patterson, L. H. (2005) Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells. Journal of Medicinal Chemistry, 48 (21). pp. 6690-6695. ISSN 0022-2623

Pors, K., Shnyder, S. D., Teesdale-Spittle, P. H., Hartley, J. A., Zloh, M., Searcey, M. and Patterson, L. H. (2006) Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: Potential for development of tumor-selective N-oxides. Journal of Medicinal Chemistry, 49 (24). pp. 7013-7023. ISSN 0022-2623

Posada, A. C., Kolar, S. L., Dusi, R. G., Francois, P., Roberts, A. A., Hamilton, C. J., Liu, G. Y. and Cheung, A. (2014) The Importance of Bacillithiol in the Oxidative Stress Response of Staphylococcus aureus. Infection and Immunity, 82 (1). pp. 316-332. ISSN 0019-9567

Pöther, Dierk-Christoph, Gierok, Philipp, Harms, Manuela, Mostertz, Jörg, Hochgräfe, Falko, Antelmann, Haike, Hamilton, Christopher, Borovok, Ilya, Lalk, Michael, Aharonowitz, Yair and Hecker, Michael (2013) Distribution and infection-related functions of bacillithiol in Staphylococcus aureus. International Journal of Medical Microbiology, 303 (3). pp. 114-123. ISSN 1438-4221

Q

Quinlan, E., Matthews, S. E. and Gunnlaugsson, T. (2006) Anion sensing using colorimetric amidourea based receptors incorporated into a 1,3-disubstituted calix[4]arene. Tetrahedron Letters, 47 (52). pp. 9333-9338. ISSN 0040-4039

Quinlan, E., Matthews, S. E. and Gunnlaugsson, T. (2007) Colorimetric recognition of anions using preorganized tetra-amidourea derived calix[4]arene sensors. The Journal of Organic Chemistry, 72 (20). pp. 7497-7503. ISSN 0022-3263

R

Rackham, Benjamin D., Howell, Lesley A., Round, Andrew N. and Searcey, Mark (2013) Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy. Organic & Biomolecular Chemistry, 11 (48). pp. 8340-8347. ISSN 1477-0520

Rajkarnikar, Arishma, Strankman, Andrew, Duran, Shayla, Vargas, Derek, Roberts, Alexandra A., Barretto, Kathryn, Upton, Heather, Hamilton, Christopher J. and Rawat, Mamta (2013) Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureus. Biochemical and Biophysical Research Communications, 436 (2). pp. 128-133. ISSN 0006-291X

Roberts, Alexandra A., Sharma, Sunil V., Strankman, Andrew W., Duran, Shayla R., Rawat, Mamta and Hamilton, Chris J. (2013) Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus. Biochemical Journal, 451 (1). pp. 69-79. ISSN 0264-6021

Robertson, James C., Hurley, Nate C., Tortorici, Marcello, Ciossani, Giuseppe, Borrello, Maria Teresa, Vellore, Nadeem A., Ganesan, A., Mattevi, Andrea and Baron, Riccardo (2013) Expanding the Druggable Space of the LSD1/CoREST Epigenetic Target: New Potential Binding Regions for Drug-Like Molecules, Peptides, Protein Partners, and Chromatin. PLoS Computational Biology, 9 (7). ISSN 1553-7358

Rosen, D, Lewis, AM, Mizote, A, Thomas, JM, Aley, PK, Vasudevan, SR, Parkesh, R, Galione, A, Izumi, M, Ganesan, A and Churchill, GC (2009) Analogues of the Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Antagonist Ned-19 Indicate Two Binding Sites on the NAADP Receptor. Journal of Biological Chemistry, 284 (50). pp. 34930-34934. ISSN 0021-9258

Rowan, A. S. and Hamilton, C. J. (2006) Recent developments in preparative enzymatic syntheses of carbohydrates. Natural Product Reports, 23 (3). pp. 412-443. ISSN 0265-0568

S

Santos, Gabriela B., Ganesan, A. and Emery, Flavio S. (2016) Oral administration of peptide-based drugs: Beyond Lipinski's rule. ChemMedChem, 11 (20). 2245–2251. ISSN 1860-7179

Sarkar, M., Hamilton, C. J. and Fairlamb, A. H. (2003) Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi. Journal of Biological Chemistry, 278 (25). pp. 22703-22708. ISSN 0021-9258

Searcey, M and Patterson, LH (2004) Resistance in cancer: A target for drug discovery. Current Medicinal Chemistry - Anti-Cancer Agents, 4 (5). pp. 457-460. ISSN 1568-0118

Searcey, M. (2002) Duocarmycins - Natures prodrugs? Current Pharmaceutical Design, 8 (15). pp. 1375-1389. ISSN 1381-6128

Searcey, M., Grewal, S. S., Madeo, F. and Tsoungas, P. G. (2003) A mild procedure for the production of secondary amines from oximes and benzisoxazoles. Tetrahedron Letters, 44 (35). pp. 6745-6747. ISSN 0040-4039

Searcey, Mark, McClean, S, Madden, B, McGown, A T and Wakelin, L P (1998) Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anti-Cancer Drug Design, 13 (8). pp. 837-855. ISSN 0266-9536

Shaheen, Farzana, Jabeen, Almas, Ashraf, Samreen, Nadeem-ul-Haque, Muhammad, Ali Shah, Zafar, Asad Ziaee, Muhammad, Dastagir, Nida and Ganesan, A. (2016) Total synthesis, structural, and biological evaluation of stylissatin A and related analogs. Journal of Peptide Science, 22 (9). pp. 607-617. ISSN 1075-2617

Shaheen, Farzana, Rizvi, Tania S., Musharraf, Syed G., Ganesan, A., Xiao, Kai, Townsend, Jared B., Lam, Kit S. and Choudhary, M. Iqbal (2012) Solid-Phase Total Synthesis of Cherimolacyclopeptide E and Discovery of More Potent Analogues by Alanine Screening. Journal of Natural Products, 75 (11). pp. 1882-1887. ISSN 0163-3864

Sharma, Sunil V., Arbach, Miriam, Roberts, Alexandra A., Macdonald, Colin J., Groom, Murree and Hamilton, Chris J. (2013) Biophysical Features of Bacillithiol, the Glutathione Surrogate of Bacillus subtilis and other Firmicutes. ChemBioChem, 14 (16). pp. 2160-2168. ISSN 1439-4227

Sharp, A, Crabb, SJ, Johnson, PWM, Hague, A, Cutress, R, Townsend, PA, Ganesan, A and Packham, G (2009) Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions. Journal of Pharmacology and Experimental Therapeutics, 331 (2). pp. 680-689. ISSN 0022-3565

Sheng, Qiran, Neaverson, Joseph C., Mahmoud, Tasnim, Stevenson, Clare E. M., Matthews, Susan E. and Waller, Zoë A. E. (2017) Identification of new DNA i-motif binding ligands through a fluorescent intercalator displacement assay. Organic & Biomolecular Chemistry, 15 (27). pp. 5669-5673. ISSN 1477-0520

Shipitsin, Alexander V., Victorova, Lyubov S., Shirokova, Elena A., Dyatkina, Natalya B., Goryunova, Lyudmila E., Beabealashvilli, Robert Sh., Hamilton, Chris J., Roberts, Stanley M. and Krayevsky, Alexander (1999) New modified nucleoside 5′-triphosphates: synthesis, properties towards DNA polymerases, stability in blood serum and antiviral activity. Journal of the Chemical Society, Perkin Transactions 1 (8). pp. 1039-1050. ISSN 1472-7781

Silva Júnior, P. E., Rezende, L. C D, Gimenes, Julia Possamai, Maltarollo, Vinícius Goncąlves, Dale, James, Trossini, G. H G, Emery, F. S. and Ganesan, A. (2016) Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry. RSC Advances, 6 (27). pp. 22777-22780. ISSN 2046-2069

Steel, R, Cowan, J, Payerne, E, O'Connell, MA and Searcey, M (2012) Anti-inflammatory effect of a cell penetrating peptide targeting the Nrf2/Keap1 interaction. ACS Medicinal Chemistry Letters, 3. pp. 407-410. ISSN 1948-5875

Sturla, S. J., Irwin, J. J., Loeppky, R. N., Mulvihill, M. J. and Searcey, M. (2007) Chemistry in cancer research: A vital partnership. Cancer Research, 67 (14). pp. 6539-6543. ISSN 0008-5472

T

Tayler, MCD, Marie, S, Ganesan, A and Levitt, MH (2010) Determination of Molecular Torsion Angles Using Nuclear Singlet Relaxation. Journal of the American Chemical Society, 132 (24). pp. 8225-8227. ISSN 0002-7863

Tiffon, CE, Adams, JE, van der Fits, L, Wen, S, Townsend, PA, Ganesan, A, Hodges, E, Vermeer, MH and Packham, G (2011) The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells. British Journal of Pharmacology, 162 (7). pp. 1590-1602. ISSN 1476-5381

Tortorici, Marcello, Borrello, Maria Teresa, Tardugno, Maria, Chiarelli, Laurent R, Pilotto, Simona, Ciossani, Giuseppe, Vellore, Nadeem A, Bailey, Sarah G, Cowan, Jonathan, O'Connell, Maria, Crabb, Simon J, Packham, Graham, Mai, Antonello, Baron, Riccardo, Ganesan, A and Mattevi, Andrea (2013) Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. ACS Chemical Biology, 8 (8). pp. 1677-1682. ISSN 1554-8937

Tsoungas, P. G. and Searcey, M. (2001) A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators. Tetrahedron Letters, 42 (37). pp. 6589-6592. ISSN 0040-4039

U

Ukhatskaya, E.V., Kurkov, S.V., Hjálmarsdóttir, M.A., Karginov, V.A., Matthews, S.E., Rodik, R.V., Kalchenko, V.I. and Loftsson, T. (2013) Cationic quaternized aminocalix[4]arenes:Cytotoxicity, haemolytic and antibacterial activities. International Journal of Pharmaceutics, 458 (1). pp. 25-30. ISSN 0378-5173

Ukhatskaya, E.V., Kurkov, S.V., Matthews, S.E. and Loftsson, T. (2014) Antifungal drug solubilizing activity and self-aggregation ability of cationic aminocalix[4]arene in comparison to SBEβCD:effect of addition of water-soluble polymer. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 79 (1-2). pp. 47-55. ISSN 0923-0750

Ukhatskaya, E.V., Kurkov, S.V., Matthews, S.E. and Loftsson, T. (2013) Encapsulation of drug molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in biopharmaceutical field. Journal of Pharmaceutical Sciences, 102 (10). pp. 3485-3512. ISSN 0022-3549

Ukhatskaya, E.V., Kurkov, S.V., Rodik, R.V., Kalchenko, V.I., Matthews, S.E., Jansook, P. and Loftsson, T. (2014) Surface activity and self-aggregation ability of three cationic quaternized aminocalix[4]arenes. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 79 (3). pp. 473-483. ISSN 0923-0750

Ukhatskaya, Elena V., Kurkov, Sergey V., Matthews, Susan E, El Fagui, Amani, Amiel, Catherine, Dalmas, Florent and Loftsson, Thorsteinn (2010) Evaluation of a cationic calix[4]arene: Solubilization and self-aggregation ability. International Journal of Pharmaceutics, 402 (1-2). pp. 10-19.

W

Waller, Z.A.E., Bowen, R and Edwards, H (2006) Raman spectroscopic and structural investigation of 1,4-diphenylbuta-1,3-diene and selected monomethyl and dimethyl substituted homologues. Analytica Chimica Acta, 580 (1). pp. 47-54. ISSN 1873-4324

Waller, Z.A.E., Sewitz, Sven A., Hsu, Shang-Te Danny and Balasubramanian, Shankar (2009) A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression. Journal of the American Chemical Society, 131 (35). pp. 12628-12633.

Waller, Z.A.E., Shirude, Pravin S., Rodriguez, Raphaël and Balasubramanian, Shankar (2008) Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition. Chemical Communications (12). pp. 1467-1469. ISSN 1359-7345

Waller, Zoë A E, Howell, Lesley A, Macdonald, Colin J, O'Connell, Maria A and Searcey, Mark (2014) Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Biochemical and Biophysical Research Communications, 447 (1). pp. 128-32. ISSN 0006-291X

Watanabe, Kenji, Hotta, Kinya, Praseuth, Alex P., Searcey, Mark, Wang, Clay C. C., Oguri, Hiroki and Oikawa, Hideaki (2009) Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli. ChemBioChem, 10 (12). pp. 1965-1968. ISSN 1439-7633

Wen, S, Packham, G and Ganesan, A (2008) Macrolactamization versus Macrolactonization: Total Synthesis of FK228, the Depsipeptide Histone Deacetylase Inhibitor†. The Journal of Organic Chemistry, 73 (23). pp. 9353-9361. ISSN 0022-3263

Wen, Shijun, Carey, Krystle L., Nakao, Yoichi, Fusetani, Nobuhiro, Packham, Graham and Ganesan, A. (2007) Total Synthesis of Azumamide A and Azumamide E, Evaluation as Histone Deacetylase Inhibitors, and Design of a More Potent Analogue. Organic Letters, 9 (6). pp. 1105-1108. ISSN 1523-7060

Williams, R, Searcey, M and Potter, B (2006) Cancer treatments for the new millennium. Drug News & Perspectives, 19 (4). pp. 229-32. ISSN 0214-0934

Wlassoff, W. A., Finlay, R. M. J. and Hamilton, C. J. (2007) Practical synthesis of sugar monophosphonucleotides. Synthetic Communications, 37 (17). pp. 2927-2934. ISSN 0039-7911

Wright, A. J., Matthews, S. E., Fischer, W. B. and Beer, P. D. (2001) Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. Chemistry - A European Journal, 7 (16). pp. 3474-3481. ISSN 0947-6539

Wright, Elisé P, Huppert, Julian L and Waller, Zoë A E (2017) Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH. Nucleic Acids Research, 2017 (1). ISSN 0305-1048

Wright, Elisé P., Day, Henry A., Ibrahim, Ali M., Kumar, Jeethendra, Boswell, Leo J. E., Huguin, Camille, Stevenson, Clare E. M., Pors, Klaus and Waller, Zoë A. E. (2016) Mitoxantrone and analogues bind and stabilize i-motif forming DNA sequences. Scientific Reports, 6. ISSN 2045-2322

Y

Yurek-George, Alexander, Cecil, Alexander Richard Liam, Mo, Alex Hon Kit, Wen, Shijun, Rogers, Helen, Habens, Fay, Maeda, Satoko, Yoshida, Minoru, Packham, Graham and Ganesan, A. (2007) The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor. Journal of Medicinal Chemistry, 50 (23). pp. 5720-5726. ISSN 0022-2623

Z

Zhu, Daqian, Wu, Yongcheng, Wu, Baojian, Luo, Bingling, Ganesan, A., Wu, Fu-hai, Pi, Rongbiao, Huang, Peng and Wen, Shijun (2014) Three-Component Pd/Cu-Catalyzed Cascade Reactions of Cyclic Iodoniums, Alkynes, and Boronic Acids: An Approach to Methylidenefluorenes. Organic Letters, 16 (9). pp. 2350-2353. ISSN 1523-7060

This list was generated on Sun Mar 24 14:01:58 2019 GMT.