Items where Author is "Watson, Alastair"

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Martínez-Sánchez, Luz DC., Pradhan, Rashmita, Ngo, Phuong A., Erkert, Lena, Becker, Lukas S., Watson, Alastair J., Atreya, Imke, Neurath, Markus F. and López-Posadas, Rocío (2020) An intravital microscopy-based approach to assess intestinal permeability and epithelial cell shedding performance. Journal of Visualized Experiments, 2020 (166). ISSN 1940-087X

Hughes, Kevin R., Schofield, Zoe, Dalby, Matthew J., Caim, Shabhonam, Chalklen, Lisa, Bernuzzi, Federico, Alcon-Giner, Cristina, Le Gall, Gwénaëlle, Watson, Alastair J.M. and Hall, Lindsay J. (2020) The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding. FASEB Journal, 34 (5). pp. 7075-7088. ISSN 0892-6638

Schleier, Lena, Wiendl, Maximilian, Heidbreder, Karin, Binder, Marie-Theres, Atreya, Raja, Rath, Timo, Becker, Emily, Schulz-Kuhnt, Anja, Stahl, Annette, Schulze, Lisa Lou, Ullrich, Karen, Merz, Simon F., Bornemann, Lea, Gunzer, Matthias, Watson, Alastair J. M., Neufert, Clemens, Atreya, Imke, Neurath, Markus F. and Zundler, Sebastian (2020) Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing. Gut, 69 (2). pp. 252-263. ISSN 0017-5749

Patel, Meha, Watson, Alastair J. M. and Rushbrook, Simon (2019) A Mechanistic Insight Into the Role of Gut Microbiota in the Pathogenesis of Primary Sclerosing Cholangitis. Gastroenterology, 157 (6). pp. 1686-1688. ISSN 0016-5085

Zhang, Jiajia, Haines, Charles, Watson, Alastair J. M., Hart, Andrew R., Platt, Mary Jane, Pardoll, Drew M., Cosgrove, Sara E., Gebo, Kelly A. and Sears, Cynthia L. (2019) Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: a matched case-control study. Gut, 68 (11). pp. 1971-1978. ISSN 0017-5749

Thomas, John, Divekar, Devina, Brooks, Johanne and Watson, Alastair J. M. (2019) Gut Microbes Drive T Cell Infiltration Into Colorectal Cancers And Influence Prognosis. Gastroenterology, 156 (6). pp. 1926-1928. ISSN 0016-5085

Jones, Emily J, Matthews, Zoe J, Gul, Lejla, Sudhakar, Padhmanand, Treveil, Agatha, Divekar, Devina, Buck, Jasmine, Wrzesinski, Tomasz, Jefferson, Matthew, Armstrong, Stuart D, Hall, Lindsay J, Watson, Alastair J M, Carding, Simon R, Haerty, Wilfried, Di Palma, Federica, Mayer, Ulrike, Powell, Penny P, Hautefort, Isabelle, Wileman, Tom and Korcsmaros, Tamas (2019) Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy. Disease Models & Mechanisms, 12 (3). ISSN 1754-8403

Thomas, Martin Geoffrey, Bayliss, Carrie, Bond, Simon, Dowling, Francis, Galea, James, Jairath, Vipul, Lamb, Christopher, Probert, Christopher, Timperley-Preece, Elizabeth, Watson, Alastair, Whitehead, Lynne, Williams, John G., Parkes, Miles, Kaser, Arthur and Raine, Tim (2019) Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: The IASO trial. BMJ Open, 9 (2). ISSN 2044-6055

Parker, Aimée, Vaux, Laura, Patterson, Angela, Modasia, Amisha, Muraro, Danial, Fletcher, Alexander, Byrne, Helen, Maini, Phillip, Watson, Alastair and Pin, Carmen (2019) Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation. Cell Death & Disease, 10 (2). ISSN 2041-4889

Biancheri, Paolo and Watson, Alastair J. M. (2019) High Mucosal Plasma Cell Numbers and Low Serum TREM-1 Levels May Predict Nonresponsiveness to Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease. Gastroenterology, 156 (1). pp. 279-281. ISSN 0016-5085

Patterson, Angela M. and Watson, Alastair J.M. (2018) Intraepithelial Cells Are the First Line of Defense Against Enteric Infection. Gastroenterology, 155 (5). pp. 1640-1642. ISSN 0016-5085

Muraro, Daniele, Parker, Aimee, Vaux, Laura, Filipi, Sarah, Ahmet, Axel A, Fletcher, Alexander G, Watson, Alastair JM, Pin, Carmen, Maini, Phillip K and Byrne, Helen M (2018) Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium. Journal of The Royal Society Interface, 15 (145). ISSN 1742-5689

Biancheri, Paolo, Divekar, Devina and Watson, Alastair JM (2018) Could Fecal Transplantation Become Part of PD-1-Based Immunotherapy, Due to Effects of the Intestinal Microbiome? Gastroenterology, 154 (6). pp. 1845-1847. ISSN 0016-5085

Zundler, Sebastian, Schillinger, Daniella, Fischer, Anika, Atreya, Raja, Lopez-Posadas, Rocio, Watson, Alastair, Neufert, Clemens, Atreya, Imke and Neurath, Markus F. (2017) Blockade of αEβ7 integrin suppresses accumulation of CD8+ and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo. Gut, 66 (11). pp. 1936-1948. ISSN 0017-5749

Maclaren, Oliver J., Parker, Aimée, Pin, Carmen, Carding, Simon R., Watson, Alastair J. M., Fletcher, Alexander G., Byrne, Helen M. and Maini, Phillip K. (2017) A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium. PLoS Computational Biology, 13 (7). ISSN 1553-734X

Patterson, Angela and Watson, Alastair (2017) Deciphering the complex signalling systems that regulate intestinal epithelial cell death processes and shedding. Frontiers in Immunology, 8. ISSN 1664-3224

Biancheri, Paolo and Watson, Alastair (2017) The relative contributions of the gut microbiome, host genetics, and environment to cytokine responses to microbial stimulation. Gastroenterology, 152 (8). 2068–2070. ISSN 0016-5085

Brooks, Johanne, Watson, Alastair and Korcsmaros, Tamas (2017) Omics approaches to identify potential biomarkers of inflammatory diseases in the focal adhesion complex. Genomics, Proteomics & Bioinformatics, 15 (2). 101–109. ISSN 2210-3244

Zundler, Sebastian, Fischer, Anika, Schillinger, Daniella, Binder, Marie-Theres, Atreya, Raja, Rath, Timo, Lopez-Posadas, Rocio, Voskens, Caroline, Watson, Alastair, Atreya, Imke, Neufert, Clemens and Neurath, Markus (2017) The α4β1 homing pathway is essential for ileal homing of Crohn's disease effector T cells in vivo. Inflammatory Bowel Diseases, 23 (3). pp. 379-391. ISSN 1078-0998

Parker, Aimee, Maclaren, Oliver J., Fletcher, Alexander G., Muraro, Daniele, Kreuzaler, Peter A., Byrne, Helen M., Maini, Philip K., Watson, Alastair J. M. and Pin, Carmen (2017) Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi. The FASEB Journal, 31 (2). pp. 636-649. ISSN 0892-6638

Hughes, Kevin R., Harnisch, Lukas C., Alcon-Giner, Cristina, Mitra, Suparna, Wright, Chris J., Ketskemety, Jennifer, van Sinderen, Douwe, Watson, Alastair J.M. and Hall, Lindsay (2017) Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner. Inflammatory Bowel Diseases, 7 (1). ISSN 1078-0998

Miguel, Jennifer, Maxwell, Adrienne, Hsieh, Jonathon, Harnisch, Lukas, Alam, Denise Al, Polk, Brent, Lien, Ching-Ling, Watson, Alastair and Frey, Mark R (2017) Epidermal growth factor suppresses intestinal epithelial cell shedding both in vitro and in vivo via a MAPK dependent pathway. Journal of Cell Science, 130 (1). pp. 90-96. ISSN 0021-9533

Fischer, Anika, Zundler, Sebastian, Atreya, Raja, Rath, Timo, Voskens, Caroline, Hirschmann, Simon, López-Posadas, Rocío, Watson, Alastair, Becker, Christoph, Schuler, Gerold, Neufert, Clemens, Atreya, Imke and Neurath, Markus F. (2016) Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut, 65 (10). pp. 1642-1664. ISSN 0017-5749

Watson, Alastair J.M. (2016) Confocal laser endomicroscopy in the management of IBD: Clearly superior? Digestive Diseases and Sciences, 61 (7). pp. 1785-1787. ISSN 0163-2116

Watson, Alastair J. M., Biancheri, Paolo and Patterson, Angela (2016) The mucosal microbiome and recurrence after surgery for Crohn’s disease. Gastroenterology, 150 (7). pp. 1682-1684. ISSN 0016-5085

Kelly, Paul, Besa, Ellen, Zyambo, Kanekwa, Louis-Auguste, John, Lees, James, Banda, Themba, Soko, Rose, Banda, Rosemary, Amadi, Beatrice and Watson, Alastair (2016) Endomicroscopic and transcriptomic analysis of impaired barrier function and malabsorption in environmental enteropathy. PLoS Neglected Tropical Diseases, 10 (4). ISSN 1935-2735

Martini, Eva, Wittkopf, Nadine, Gunther, Claudia, Leppkes, Moritz, Okada, Hitoshi, Watson, Alastair J., Podstawa, Eva, Backert, Ingo, Amann, Kerstin, Neurath, Markus F. and Becker, Christoph (2016) Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis. Cell Reports, 14 (5). pp. 1062-1073. ISSN 2211-1247

Lopez-Posadas, Rocio, Becker, Christoph, Gunther, Claudia, Tenzer, Stefan, Amann, Kerstin, Billmeier, Ulrike, Atreya, Raja, Fiorino, Gionata, Vetrano, Stefania, Danese, Silvio, Ekici, Arif B., Wirtz, Stefan, Thonn, Veronika, Watson, Alastair, Brakebusch, Cord, Bergo, Martin, Neurath, Marcus and Atreya, Imke (2016) Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. Journal of Clinical Investigation, 126 (2). pp. 611-626. ISSN 0021-9738

Kelley, Alex, Beeching, Nick, Roberts, Paul, Watson, Alastair and Beadsworth, Mike (2016) Clostridium difficile: a healthcare associated infection of unknown significance in adults in sub-Saharan Africa. Malawi Medical Journal, 28 (2). ISSN 1995-7270

Brooks, Johanne and Watson, Alastair (2015) The Enteric Virome in Inflammatory Bowel Disease. Gastroenterology, 149 (4). pp. 1120-1121. ISSN 0016-5085

Dammann, Kyle, Khare, Vineeta, Lang, Michaela, Claudel, Thierry, Harpain, Felix, Granofszky, Nicolas, Evstatiev, Rayko, Williams, Jonathan M., Pritchard, D. Mark, Watson, Alastair and Gasche, Christoph (2015) PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853 (10, Part A). 2349–2360. ISSN 0167-4889

Watson, Alastair (2015) Claudins and barrier dysfunction in intestinal inflammation: cause or consequence? Gut, 64 (10). pp. 1501-1502. ISSN 0017-5749

Huels, David, Ridgeway, Rachel, Radulescu, Sorina, Leushacke, Marc, Campbell, Andrew, Biswas, Sujata, Leedham, Simon, Serra, Stefano, Chetty, Runjan, Moreaux, Guenieve, Parry, Lee, Matthews, James, Song, Fei, Hedley, Ann, Kalna, Gabriela, Ceteci, Fatih, Reed, Karen R, Meniel, Valerie S, Maguire, Aoife, Soderberg, Ola, Barker, Nicholas, Watson, Alastair, Larue, Lionel and Sansom, Owen (2015) E-cadherin can limit the transforming properties of activating β-catenin mutations. The EMBO Journal, 34 (18). pp. 2321-2333. ISSN 0261-4189

Man, Angela L., Bertelli, Eugenio, Rentini, Silvia, Regoli, Mari, Briars, Graham, Marini, Mario, Watson, Alastair J.M. and Nicoletti, Claudio (2015) Age-associated modifications of intestinal permeability and innate immunity in human small intestine. Clinical Science, 129 (7). pp. 515-527. ISSN 0143-5221

Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J. and Pritchard, D. M. (2015) Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip. Veterinary Pathology, 52 (3). pp. 445-455. ISSN 1544-2217

Gunther, Claudia, Buchen, Barbara, He, Gui-Wei, Hornef, Mathias, Torow, Natalia, Neumann, Helmut, Wittkopf, Nadine, Martini, Eva, Basic, Marijana, Bleich, André, Watson, Alastair J. M., Neurath, Markus F. and Becker, Christoph (2015) Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways. Gut, 64 (4). pp. 601-610. ISSN 0017-5749

Sreekumar, J, France, N, Taylor, S, Matthews, T, Turner, P, Bliss, P, Brook, A H and Watson, A J M (2015) Diagnosis of Helicobacter pylori by carbon-13 urea breath test using a portable mass spectrometer. Sage Open Medicine, 3. ISSN 2050-3121

Bischoff, Stephan C, Barbara, Giovanni, Buurman, Wim, Ockhuizen, Theo, Schulzke, Jörg-dieter, Serino, Matteo, Tilg, Herbert, Watson, Alastair and Wells, Jerry (2014) Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterology, 14. ISSN 1471-230X

Hall, Lindsay J, Walshaw, John and Watson, Alastair J M (2014) Gut Microbiome in New-Onset Crohn's Disease. Gastroenterology, 147 (4). 932–934. ISSN 0016-5085

Sandek, Anja, Swidsinski, Alexander, Schroedl, Wieland, Watson, Alastair, Valentova, Miroslava, Herrmann, Ralph, Scherbakov, Nadja, Cramer, Larissa, Rauchhaus, Mathias, Grosse-Herrenthey, Anke, Krueger, Monika, von Haehling, Stephan, Doehner, Wolfram, Anker, Stefan D. and Bauditz, Juergen (2014) Intestinal blood flow in patients with chronic heart failure: A link with bacterial growth, gastrointestinal symptoms, and cachexia. Journal of the American College of Cardiology, 64 (11). pp. 1092-1102. ISSN 0735-1097

Beadsworth, Michael, Beeley, Alex, Roberts, Paul, Farragher, Brian, Watson, Alastair and Beeching, Nick (2014) Clostridium difficile Toxin in Adult Inpatients in an Urban Hospital in Malawi: Associations with HIV Status, CD4 Count and Diarrhoea. International Journal of Tropical Medicine, 9 (1). pp. 7-9. ISSN 1818-779X

Parker, Aimée and Watson, Alastair J M (2014) Details Unfold: The ER Stress Response in Intestinal Inflammation and Cancer. Gastroenterology, 147 (2). pp. 531-3. ISSN 0016-5085

Watson, Alastair J. M. (2014) Confocal Laser Endomicroscopy and NSAID Enteropathy: Where Next? Digestive Diseases and Sciences, 59 (7). pp. 1344-1346. ISSN 0163-2116

Lim, Lee Guan, Neumann, Janina, Hansen, Torsten, Goetz, Martin, Hoffman, Arthur, Neurath, Markus Friedrich, Galle, Peter R, Chan, Yiong H, Kiesslich, Ralf and Watson, Alastair (2014) Confocal endomicroscopy identifies loss of local barrier function in the duodenum of patients with Crohn's disease and ulcerative colitis. Inflammatory Bowel Diseases, 20 (5). pp. 892-900.

Parsons, Bryony N, Wigley, Paul, Simpson, Hannah L, Williams, Jonathan M, Humphrey, Suzie, Salisbury, Anne-Marie, Watson, Alastair J M, Fry, Stephen C, O'Brien, David, Roberts, Carol L, O'Kennedy, Niamh, Keita, Asa V, Söderholm, Johan D, Rhodes, Jonathan M and Campbell, Barry J (2014) Dietary Supplementation with Soluble Plantain Non-Starch Polysaccharides Inhibits Intestinal Invasion of Salmonella Typhimurium in the Chicken. PLoS One, 9 (2). ISSN 1932-6203

Goode, Elizabeth, Warburton, Richard, Gelson, William and Watson, Alastair (2013) Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function. Gastroenterology. pp. 1481-1484. ISSN 0016-5085

Williams, Jonathan M, Duckworth, Carrie A, Watson, Alastair J M, Frey, Mark R, Miguel, Jennifer C, Burkitt, Michael D, Sutton, Robert, Hughes, Kevin R, Hall, Lindsay J, Caamaño, Jorge H, Campbell, Barry J and Pritchard, D Mark (2013) A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Disease Models & Mechanisms, 6 (6). pp. 1388-1399. ISSN 1754-8411

Hammoudi, Abeer, Song, Fei, Reed, Karen R, Jenkins, Rosalind E, Meniel, Valerie S, Watson, Alastair J M, Pritchard, D Mark, Clarke, Alan R and Jenkins, John R (2013) Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). Biochemical and Biophysical Research Communications, 440 (3). pp. 364-370. ISSN 0006-291X

Chan, Simon and Watson, Alastair J M (2013) Bacterial translocation influences the response to biological therapy in Crohn's disease. Gastroenterology, 145 (4). pp. 898-901. ISSN 0016-5085

Méniel, Valérie, Song, Fei, Phesse, Toby, Young, Madeleine, Poetz, Oliver, Parry, Lee, Jenkins, John R, Williams, Geraint T, Dunwoodie, Sally L, Watson, Alastair and Clarke, Alan R (2013) Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genetics, 9 (8). ISSN 1553-7404

Watson, AJM and Hall, LJ (2013) Regulation of host gene expression by gut microbiota. Gastroenterology, 144 (4). pp. 841-4. ISSN 0016-5085

Becker, Christoph, Watson, Alastair J and Neurath, Markus F (2013) Complex roles of caspases in the pathogenesis of inflammatory bowel disease. Gastroenterology, 144 (2). pp. 283-93. ISSN 0016-5085

Watson, Alastair J M, Hall, Lindsay J and Hughes, Kevin R (2012) Cell shedding:old questions answered. Gastroenterology, 143 (5). pp. 1389-1391. ISSN 1528-0012

Goode, Elizabeth C and Watson, Alastair J M (2012) Mesenteric fat as a source of CRP and target for bacterial translocation in Crohn's disease. Gastroenterology, 143 (2). pp. 496-8. ISSN 0016-5085

Kiesslich, R, Duckworth, C A, Moussata, D, Gloeckner, A, Lim, L G, Goetz, M, Pritchard, D M, Galle, P R, Neurath, M F and Watson, A J M (2012) Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut, 61 (8). pp. 1146-1153. ISSN 0017-5749

Watson, Alastair J M and Hughes, Kevin R (2012) TNF-α-induced intestinal epithelial cell shedding:implications for intestinal barrier function. Annals of the New York Academy of Sciences, 1258. pp. 1-8. ISSN 0077-8923

Pin, Carmen, Watson, Alastair J M and Carding, Simon R (2012) Modelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal crypt. PLoS One, 7 (5). ISSN 1932-6203

Hall, Lindsay J and Watson, Alastair J M (2012) Role of autophagy in NOD2-induced inflammation in Crohn's disease. Gastroenterology, 142 (4). pp. 1032-1034. ISSN 1528-0012

McNamara, Anne V, Barclay, Monica, Watson, Alastair J M and Jenkins, John R (2012) Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. Biochemical Pharmacology, 83 (3). pp. 355-367. ISSN 0006-2952

Leiper, Keith, Martin, Kate, Ellis, Anthony, Subramanian, Sreedhar, Watson, Alastair J, Christmas, Steve E, Howarth, Deborah, Campbell, Fiona and Rhodes, Jonathan M (2011) Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis. Gut, 60 (11). pp. 1520-1526. ISSN 0017-5749

Watson, Alastair J M (2011) Effect of neonatal nutrition on long-term barrier function and gut inflammation. Gastroenterology, 141 (5). pp. 1939-1941. ISSN 1528-0012

Goetz, Martin, Watson, Alastair and Kiesslich, Ralf (2011) Confocal laser endomicroscopy in gastrointestinal diseases. Journal of Biophotonics, 4 (7-8). pp. 498-508. ISSN 1864-0648

Stallmach, Andreas, Schmidt, Carsten, Watson, Alastair and Kiesslich, Ralf (2011) An unmet medical need:advances in endoscopic imaging of colorectal neoplasia. Journal of Biophotonics, 4 (7-8). pp. 482-489. ISSN 1864-0648

Watson, Alastair J M and Hart, Andrew R (2011) Environmental risk factors for inflammatory bowel disease:microbes, diet, and the appendix. Gastroenterology, 141 (2). pp. 768-770. ISSN 0016-5085

Guan, Yanfang, Watson, Alastair J M, Marchiando, Amanda M, Bradford, Emily, Shen, Le, Turner, Jerrold R and Montrose, Marshall H (2011) Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells. American Journal of Physiology - Cell Physiology, 300 (6). C1404-1414.

Marchiando, Amanda M, Shen, Le, Graham, W Vallen, Edelblum, Karen L, Duckworth, Carrie A, Guan, Yanfang, Montrose, Marshall H, Turner, Jerrold R and Watson, Alastair J M (2011) The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology, 140 (4). pp. 1208-1218. ISSN 1528-0012

Watson, Alastair J M and Tremelling, Mark (2011) Mucosal gene expression signatures that predict response of ulcerative colitis to infliximab. Gastroenterology, 140 (2). pp. 729-731. ISSN 1528-0012

Moussata, Driffa, Goetz, Martin, Gloeckner, Annabel, Kerner, Marcus, Campbell, Barry, Hoffman, Arthur, Biesterfeld, Stephan, Flourie, Bernard, Saurin, Jean-Christophe, Galle, Peter R, Neurath, Markus F, Watson, Alastair J M and Kiesslich, Ralf (2011) Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo. Gut, 60 (1). pp. 26-33. ISSN 0017-5749

Moussata, Driffa, Goetz, Martin, Gloeckner, Annabel, Kerner, Marcus, Campbell, Barry, Hoffman, Arthur, Biesterfeld, Stephan, Flourie, Bernard, Saurin, Jean-Christophe, Galle, Peter R., Neurath, Markus F., Watson, Andrew J. M. and Kiesslich, Ralf (2011) Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in IBD in vivo. Gut, 60 (1). pp. 26-33.

Duckworth, Carrie A and Watson, Alastair J (2011) Analysis of epithelial cell shedding and gaps in the intestinal epithelium. Methods in Molecular Biology, 763. pp. 105-114. ISSN 1940-6029

Watson, Alastair J M and Collins, Paul D (2011) Colon cancer:a civilization disorder. Digestive Diseases, 29 (2). pp. 222-228. ISSN 1421-9875

Watson, Alastair J M and Collins, Paul (2010) Treatment of inflammatory bowel disease with genetically engineered bacteria. Gastroenterology, 139 (2). pp. 685-687. ISSN 1528-0012

Marchiando, Amanda M, Shen, Le, Graham, W Vallen, Weber, Christopher R, Schwarz, Brad T, Austin, Jotham R, Raleigh, David R, Guan, Yanfang, Watson, Alastair J M, Montrose, Marshall H and Turner, Jerrold R (2010) Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. Journal of Cell Biology, 189 (1). pp. 111-126. ISSN 0021-9525

Watson, AJM (2010) The new 'connexin' to the pathogenesis of E coli diarrhoea. Gut, 59 (2). pp. 154-155.

Watson, Alastair J M and Duckworth, Carrie A (2010) Gut microbiota control gut permeability through GLP-2. Gastroenterology, 138 (2). pp. 779-781. ISSN 1528-0012

Baumgartner, Heidi K, Gerasimenko, Julia V, Thorne, Christopher, Ferdek, Pawel, Pozzan, Tullio, Tepikin, Alexei V, Petersen, Ole H, Sutton, Robert, Watson, Alastair J M and Gerasimenko, Oleg V (2009) Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. The Journal of Biological Chemistry, 284 (31). pp. 20796-20803. ISSN 1083-351X

Watson, Alastair J M, Duckworth, Carrie A, Guan, Yanfang and Montrose, Marshall H (2009) Mechanisms of epithelial cell shedding in the Mammalian intestine and maintenance of barrier function. Annals of the New York Academy of Sciences, 1165. pp. 135-142. ISSN 1749-6632

Davies, Jane, Burkitt, Michael and Watson, Alastair (2009) Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. Journal of Medical Case Reports, 3 (1). p. 3. ISSN 1752-1947

Sarwar, N, Collins, PD and Watson, AJM (2009) Colorectal cancer surveillance after colon cancer resection and post-polypectomy. In: Proceedings of the Falk Symposium 164 "Intestinal disorders". Springer.

Leiper, K, Martin, K, Ellis, A, Watson, A J M, Morris, A I and Rhodes, J M (2008) Placebo controlled trial of clarithromycin in active Crohn's disease. Alimentary Pharmacology & Therapeutics, 27 (12). pp. 1233-1239. ISSN 1365-2036

Colombel, Jean-Frédéric, Watson, Alastair J M and Neurath, Markus F (2008) The 10 remaining mysteries of inflammatory bowel disease. Gut, 57 (4). pp. 429-433.

Montrose, MH and Watson, AJM (2008) Live tissue imaging with conventional confocal microscopy. In: Atlas of Endomicroscopy. Springer.

Kiesslich, Ralf, Goetz, Martin, Angus, Elizabeth M, Hu, Qiuping, Guan, Yanfang, Potten, Chris, Allen, Terry, Neurath, Markus F, Shroyer, Noah F, Montrose, Marshall H and Watson, Alastair J M (2007) Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology, 133 (6). pp. 1769-1778. ISSN 1528-0012

Tweedle, EM, Rooney, PS and Watson, AJM (2007) Screening for rectal cancer - Will it improve cure rates? Clinical Oncology, 19 (9). 639–648.

Walmesley, Alice J, Zweiri, Jehad, Christmas, Stephen E and Watson, Alastair J M (2007) Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumor immune splenocytes. Journal of Immunotherapy, 30 (6). pp. 614-623. ISSN 1524-9557

Collins, Paul D and Watson, Alastair Jm (2007) Is the rate of adenoma detection in colonoscopy influenced by the duration of colonoscope withdrawal? Nature Clinical Practice Gastroenterology and Hepatology, 4 (8). pp. 428-429. ISSN 1743-4378

Baumgartner, Heidi K, Gerasimenko, Julia V, Thorne, Christopher, Ashurst, Louise H, Barrow, Stephanie L, Chvanov, Michael A, Gillies, Stuart, Criddle, David N, Tepikin, Alexei V, Petersen, Ole H, Sutton, Robert, Watson, Alastair J M and Gerasimenko, Oleg V (2007) Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. AJP: Gastrointestinal and Liver Physiology, 293 (1). G296-307. ISSN 0193-1857

Watson, Alastair J M (2007) In vivo single-photon emission computed tomography imaging of apoptosis in Crohn's disease and anti-tumour necrosis factor therapy. Gut, 56 (4). pp. 461-463.

Bullen, Tim F, Forrest, Sharon, Campbell, Fiona, Dodson, Andrew R, Hershman, Michael J, Pritchard, D Mark, Turner, Jerrold R, Montrose, Marshall H and Watson, Alastair J M (2006) Characterization of epithelial cell shedding from human small intestine. Laboratory Investigation, 86 (10). pp. 1052-1063. ISSN 0023-6837

Bach, S P, Williamson, S E, O'Dwyer, S T, Potten, C S and Watson, A J M (2006) Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut. British Journal of Cancer, 95 (1). pp. 35-41. ISSN 0007-0920

Barker, Catherine R., Hamlett, Jane, Pennington, Stephen R., Burrows, Francis, Lundgren, Karen, Lough, Rachel, Watson, A J M and Jenkins, John R. (2006) The topoisomerase II–Hsp90 complex: A new chemotherapeutic target? International Journal of Cancer, 118 (11). pp. 2685-2693. ISSN 0020-7136

Ottewell, Penelope D, Duckworth, Carrie A, Varro, Andrea, Dimaline, Rod, Wang, Timothy C, Watson, Alastair J M, Dockray, Graham J and Pritchard, D Mark (2006) Gastrin increases murine intestinal crypt regeneration following injury. Gastroenterology, 130 (4). pp. 1169-1180. ISSN 1528-0012

Watson, AJM (2006) An overview of apoptosis and the prevention of colorectal cancer. Critical Reviews in Oncology/Hematology, 57 (2). pp. 107-121. ISSN 1040-8428

Barker, Catherine R, McNamara, Anne V, Rackstraw, Stephen A, Nelson, David E, White, Mike R, Watson, Alastair J M and Jenkins, John R (2006) Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage. Nucleic Acids Research, 34 (4). pp. 1148-1157. ISSN 0305-1048

Collins, Paul D, Mpofu, C, Watson, A J and Rhodes, Jonathan M (2006) Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease. The Cochrane Library (2). CD000279.

Collins, Paul D, Mpofu, Chiedzo, Watson, Alastair J, Rhodes, Jonathan M and Watson, Alastair J (2006) Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease. Working Paper. Wiley.

Watson, Alastair J M, Chu, Shaoyou, Sieck, Leah, Gerasimenko, Oleg, Bullen, Tim, Campbell, Fiona, McKenna, Michael, Rose, Tracy and Montrose, Marshall H. (2005) Epithelial Barrier Function In Vivo Is Sustained Despite Gaps in Epithelial Layers. Gastroenterology, 129 (3). pp. 902-912. ISSN 1528-0012

Alsheikhly, Abdul-Razzak, Zweiri, Jehad, Walmesley, AliceJ., Watson, A J M and Christmas, Stephen E. (2004) Both soluble and membrane-bound forms of Flt3 ligand enhance tumor immunity following ?suicide? gene therapy in a murine colon carcinoma model. Cancer Immunology, Immunotherapy, 53 (11). pp. 946-654. ISSN 0340-7004

Watson, AJM (2004) Apoptosis and colorectal cancer. Gut, 53 (11). pp. 1701-1709.

Ottewell, P. D., Varro, A, Dockray, GJ, Kirton, CM, Watson, AJM, Wang, TC, Dimaline, R and Pritchard, DM (2004) COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo. AJP: Gastrointestinal and Liver Physiology, 288 (3). G541-G549. ISSN 0193-1857

Dunn, Julie R, Risk, Janet M, Langan, Joanne E, Marlee, Damian, Ellis, Anthony, Campbell, Fiona, Watson, Alastair J M and Field, John K (2003) Physical and transcript map of the minimally deleted region III on 17p implicated in the early development of Barrett's oesophageal adenocarcinoma. Oncogene, 22 (26). pp. 4134-4142. ISSN 1476-5594

Ottewell, Penelope D, Watson, Alastair J M, Wang, Timothy C, Varro, Andrea, Dockray, Graham J and Pritchard, D.Mark (2003) Progastrin stimulates murine colonic epithelial mitosis after DNA damage. Gastroenterology, 124 (5). pp. 1348-1357. ISSN 1528-0012

Gerasimenko, Julia V, Gerasimenko, Oleg V, Palejwala, Altaf, Tepikin, Alexei V, Petersen, Ole H and Watson, Alastair J M (2002) Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore. Journal of Cell Science, 115 (Pt 3). pp. 485-497. ISSN 0021-9533

Bach, Simon P., Williamson, Sarah E., Marshman, Emma, Kumar, Shant, O'Dwyer, Sarah T., Potten, Christopher S. and Watson, Alastair J. M. (2001) The antioxidant n-acetylcysteine increases 5-fluorouracil activity against colorectal cancer xenografts in nude mice. Journal of Gastrointestinal Surgery, 5 (1). pp. 91-97. ISSN 1091-255X

This list was generated on Sat Dec 4 10:13:49 2021 GMT.