Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: An observational cohort study based on propensity score matching

Ye, Ying, Wen, Li, Liu, Xiyao, Wang, Lan, Liu, Yamin, Saffery, Richard, Kilby, Mark D., Tong, Chao, Qi, Hongbo and Baker, Philip (2021) Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: An observational cohort study based on propensity score matching. BMC Pregnancy and Childbirth, 21. ISSN 1471-2393

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Abstract

Background: Since the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies. Methods: This study is an observational study in two hospitals in China. Among 932 women, 277 in the First Affiliated Hospital of Chongqing Medical University were routinely treated with aspirin (100 mg daily) from 12 to 16 weeks to 35 weeks of gestational age, while 655 in Chongqing Health Center for Women and Children were not taking aspirin during pregnancy. We followed each subject and the individual details were recorded. Results: LDA significantly reduced the risk of preeclampsia (RR 0.48; 95% CI 0.24–0.95) and preterm birth 34 weeks (RR 0.50; 95% CI 0.29–0.86) and showed possible benefits to lower the rate of SGA babies (RR 0.74; 95% CI 0.55–1.00). Moreover, the risk of postpartum hemorrhage was not increased by LDA (RR 0.89; 95% CI 0.35–2.26). Conclusions: Treatment with low-dose aspirin in twin pregnancies could offer some protection against adverse pregnancy outcomes in the absence of significantly increased risk of postpartum hemorrhage.

Item Type:	Article
Additional Information:	Availability of data and materials: The data used and analyzed during the current study are available from the corresponding author on reasonable request.
Uncontrolled Keywords:	fetal growth restriction,low-dose aspirin,postpartum hemorrhage,preeclampsia,preterm birth,twin pregnancy,obstetrics and gynaecology ,/dk/atira/pure/subjectarea/asjc/2700/2729
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	07 May 2025 14:30
Last Modified:	09 May 2025 09:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99194
DOI:	10.1186/s12884-021-04217-2

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