The role of vitamin D metabolism in regulating bone turnover in adolescents with perinatally-acquired HIV in Southern Africa: A cross-sectional study in Zimbabwe and Zambia

Madanhire, Tafadzwa, Ward, Kate A., Macdougall, Amy, Mohammed, Nuredin, Filteau, Suzanne, Kasona, Lackson, Mabuda, Hilda B., Chisenga, Molly, Tang, Jonathan C. Y. ORCID: https://orcid.org/0000-0001-6305-6333, Fraser, William D., Bandason, Tsitsi, Dzavakwa, Nyasha. V., Simms, Victoria, Ferrand, Rashida. A. and Gregson, Celia L. (2024) The role of vitamin D metabolism in regulating bone turnover in adolescents with perinatally-acquired HIV in Southern Africa: A cross-sectional study in Zimbabwe and Zambia. Journal of Bone and Mineral Research. ISSN 0884-0431

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Abstract

Vitamin D dysregulation can occur in people living with HIV, disrupting calcium homeostasis and bone turnover. We aimed to investigate the potential mechanisms by which vitamin D regulates bone turnover in adolescents living with perinatally-acquired HIV (ALWH) in southern Africa. A pre-planned secondary analysis was performed of baseline data from the VITALITY trial [PACTR20200989766029] which enrolled ALWH (11-19 years) taking antiretroviral therapy for ≥6 months, and recorded socio-demographic, clinical and dietary data. After over-night fasting, vitamin D metabolites [25(OH)D, 1,25(OH)2D, 24,25(OH)2D], intact parathyroid hormone (PTH) and bone turnover markers (BTMs) [CTX and P1NP] were measured. Tandem Mass Spectrometry measured vitamin D metabolites, whilst intact PTH and BTMs were analysed by electrochemiluminescence immunoassay. Stratified by 25(OH)D [

Item Type:	Article
Additional Information:	Data availability statement: The datasets used and/or analysed during the current study are available at the London School of Hygiene and Tropical Medicine (LSHTM) DataCompass repository (DOI: 10.17037/DATA.00003868) upon reasonable request to the corresponding author. Funding information: This project is part of the EDCTP2 programme supported by the European Union (Grant number RIA2018CO-2512) The research reported in this publication was supported by the Fogarty International Center of the National Institutes of Health under Award Number D43TW011326 to TM. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. CLG is funded by the National Institute for Health and Care Research (NIHR302394). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	27 Nov 2024 10:45
Last Modified:	02 Dec 2024 01:45
URI:	https://ueaeprints.uea.ac.uk/id/eprint/97765
DOI:	10.1093/jbmr/zjae190

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