Navigation in individuals at risk for Alzheimer's disease

Lowry, Ellen, Morrissey, Sol and Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788 (2025) Navigation in individuals at risk for Alzheimer's disease. In: Encyclopedia of the Human Brain. Elsevier, pp. 265-276. ISBN 9780128204818

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Abstract

Spatial navigation has become increasingly relevant in at-risk Alzheimer's disease. The main reason is that the brain's spatial navigation network largely overlaps with areas affected by Alzheimer's disease pathophysiology, even potentially before memory symptoms emerge. In this article, we will briefly outline how Alzheimer's pathophysiology can affect spatial navigation networks in the brain. The remainder of the article will be exploring how prodromal and preclinical, sporadic- and genetic-risk for Alzheimer's disease affect spatial navigation performance before exploring the real-world diagnostic and management implications of those findings, as well as future directions the field is considering.

Item Type:	Book Section
Uncontrolled Keywords:	apoe,allocentric,alzheimer's disease,egocentric,mild cognitive impairment,path integration,spatial navigation,vascular cognitive impairment,general medicine,general neuroscience ,/dk/atira/pure/subjectarea/asjc/2700/2700
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health) Faculty of Social Sciences > Research Groups > Cognition, Action and Perception Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Centres > Public Health
Depositing User:	LivePure Connector
Date Deposited:	24 Sep 2024 12:46
Last Modified:	09 Jul 2026 10:47
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96792
DOI:	10.1016/B978-0-12-820480-1.00018-8

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