Prevalence of asymptomatic valvular heart disease in the elderly population: A community-based echocardiographic study

Tsampasian, Vasiliki, Militaru, Cristian, Kumar Parasuraman, Sathish, Loudon, Brodie L., Lowery, Crystal, Rudd, Amelia, Srinivasan, Janaki, Singh, Satnam, Dwivedi, Girish, Mahadavan, Gnanadevan, Dawson, Dana, Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941, Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752 and Frenneaux, Michael P. (2024) Prevalence of asymptomatic valvular heart disease in the elderly population: A community-based echocardiographic study. European Heart Journal-Cardiovascular Imaging, 25 (8). 1051–1058. ISSN 2047-2404

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Abstract

Aims: With an ageing population, the presence of asymptomatic valvular heart disease (VHD) in the community remains unknown. The aim of this study is to determine the prevalence and associated factors of asymptomatic VHD in individuals ≥60 years old and to evaluate the feasibility of echocardiographic screening for VHD in this population.   Methods and results: This was a prospective cohort study conducted between 2007 and 2016 in the UK. Asymptomatic patients with no prior indication for echocardiography were invited to participate and evaluated with a health questionnaire, clinical examination, and transthoracic echocardiography. A total of 10,000 individuals were invited through their general practices. A total of 5429 volunteered to participate, of whom 4237 were eligible for inclusion. VHD was diagnosed in more than a quarter of patients (28.2%). The most common types of VHD were regurgitation of the tricuspid (13.8%), mitral (12.8%), and aortic (8.3%) valves (trivial regurgitation was not included). The rate of prevalence of clinically significant VHD was 2.4% (2.2% moderate and 0.2% severe), with mitral and aortic regurgitation being the most common. The only parameter associated with significant VHD was age (odds ratio 1.07 per 1 year increment, 95% confidence interval 1.05-1.09, P < 0.001). The number needed to scan to diagnose one clinically significant case of VHD is 42 for individuals ≥60 and 15 for those ≥75 years old.     Conclusion: Asymptomatic VHD is present in a significant proportion of otherwise healthy individuals without known VHD over 60 years old. Age is strongly associated with an increased incidence of significant VHD.

Item Type: Article
Additional Information: Data availability statement: All data are available from the corresponding author on request. Funding information: This study was funded by the British Heart Foundation Project Grant to M.P.F.: PG/08/076/25549.
Uncontrolled Keywords: asymptomatic,echocardiography,epidemiology,silent,valvular heart disease,cardiology and cardiovascular medicine,radiology nuclear medicine and imaging ,/dk/atira/pure/subjectarea/asjc/2700/2705
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care
Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Centres > Population Health
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Depositing User: LivePure Connector
Date Deposited: 19 Jul 2024 10:32
Last Modified: 25 Sep 2024 17:56
URI: https://ueaeprints.uea.ac.uk/id/eprint/95961
DOI: 10.1093/ehjci/jeae127

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