Chromatin proteins involved in the initiation of DNA replication

Rowles, Alison and Blow, J. Julian (1997) Chromatin proteins involved in the initiation of DNA replication. Current Opinion in Genetics and Development, 7 (2). pp. 152-157. ISSN 0959-437X

Full text not available from this repository. (Request a copy)


Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G1 to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.

Item Type: Article
Faculty \ School:
Depositing User: LivePure Connector
Date Deposited: 11 Jun 2024 09:30
Last Modified: 11 Jun 2024 09:30
DOI: 10.1016/S0959-437X(97)80123-2

Actions (login required)

View Item View Item